{"id":"W4403512422","doi":"10.1093/neuonc/noae144.473","title":"P27.11.A GLOBAL EXPANSION OF GBM AGILE: A PHASE 2/3 ADAPTIVE PLATFORM TRIAL TO EVALUATE MULTIPLE REGIMENS IN NEWLY DIAGNOSED AND RECURRENT GLIOBLASTOMA","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Statistical Methods in Clinical Trials","field":"Mathematics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Glioblastoma; Agile software development; Medicine; Phase (matter); Oncology; Internal medicine; Computer science; Cancer research; Software engineering; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002475409,0.0009922964,0.0009796526,0.0003410201,0.0003231449,0.000868779,0.0005496581,0.0007599468,0.004323743],"category_scores_gemma":[0.001610178,0.0002172919,0.001175777,0.0003407079,0.00101861,0.000862125,0.0008982924,0.003043009,0.0007120207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007385774,"about_ca_system_score_gemma":0.00172726,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006958065,"about_ca_topic_score_gemma":0.001680174,"domain_scores_codex":[0.9993579,0.0003524406,0.00002722837,0.000111387,0.00005892854,0.0000920554],"domain_scores_gemma":[0.9991727,0.0001579673,0.0001190755,0.00008120116,0.00007003371,0.0003988572],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5261253,0.02909078,0.007298133,0.002359269,0.002545712,0.0005538335,0.0004757515,0.01280848,0.03280621,0.004297808,0.03792062,0.3437181],"study_design_scores_gemma":[0.6235442,0.3162085,0.01353665,0.0003494179,0.001162342,0.0004915961,0.0002007926,0.006835757,0.008876367,0.005487327,0.02320499,0.0001021437],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.967633,0.004475036,0.004884784,0.003440152,0.000380577,0.006071387,0.003551371,0.0005669121,0.008996749],"genre_scores_gemma":[0.971329,0.002404671,0.007171175,0.00336009,0.0002087494,0.006930493,0.003699812,0.0001643156,0.00473166],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004323743,"threshold_uncertainty_score":0.01446438,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3538821033136119,"score_gpt":0.5455905287246768,"score_spread":0.191708425411065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}