{"id":"W4403512567","doi":"10.1136/ard-2024-225876","title":"Single-cell transcriptomics reveal potent extrafollicular B cell response linked with granzyme K+ CD8 T cell activation in lupus kidney","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Systemic Lupus Erythematosus Research","field":"Medicine","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Science and Technology Plan Project of Taizhou; Beijing Institute of Genomics, Chinese Academy of Sciences; Renji Hospital; Shanghai Hospital Development Center; Chinese Academy of Sciences; Science and Technology Program of Suzhou; National Natural Science Foundation of China","keywords":"Medicine; Cytotoxic T cell; Granzyme B; Systemic lupus erythematosus; Kidney; B cell; CD8; Cell; Granzyme; Immunology; Granzyme A; T cell; Molecular biology; Immune system; Biology; Perforin; Pathology; Antibody; Internal medicine; Biochemistry; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00012007,0.0001410109,0.000237283,0.0002865031,0.000158057,0.0003339279,0.0001017214,0.0003005312,0.001073159],"category_scores_gemma":[0.0001072581,0.0001007909,0.0002178363,0.000194952,0.0001597655,0.0001285274,0.000167662,0.0002541067,0.0003151159],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001280032,"about_ca_system_score_gemma":0.00009122193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002642099,"about_ca_topic_score_gemma":0.0004202318,"domain_scores_codex":[0.9998949,0.000009949289,0.000007142746,0.00004380239,0.0000228904,0.00002129938],"domain_scores_gemma":[0.9999386,0.00001149955,0.00001704745,0.000006596661,0.00001128389,0.0000149753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0001664363,0.000009305833,0.004763689,0.00003943855,0.0000124257,0.000109305,0.00004742263,0.00007886383,0.993004,0.00002171367,0.00004465842,0.001702746],"study_design_scores_gemma":[0.00004393836,0.0004396487,0.4962752,0.0000229928,0.0001286135,0.002538275,0.0006045291,0.004034546,0.4916177,0.0005846063,0.003683292,0.00002671911],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953022,0.0006012563,0.002342823,0.00003873558,0.00001066075,0.00001267186,0.001193412,0.00005374385,0.0004445109],"genre_scores_gemma":[0.9955511,0.0003085687,0.002285435,0.0000987664,0.00001639658,0.00002916204,0.0009912432,0.00002040517,0.0006988935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001073159,"threshold_uncertainty_score":0.003590047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03644094703031948,"score_gpt":0.2851039771190901,"score_spread":0.2486630300887706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}