{"id":"W4403512673","doi":"10.1093/neuonc/noae144.253","title":"P14.02.B A MULTICENTER, RANDOMIZED, CONTROLLED TRIAL OF FOCUSED-ULTRASOUND-MEDIATED BLOOD-BRAIN BARRIER DISRUPTION PLUS SYSTEMIC PEMBROLIZUMAB FOR PATIENTS WITH NSCLC BRAIN METASTASES (LIMITLESS)","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Toronto; Sunnybrook Health Science Centre","funders":"","keywords":"Pembrolizumab; Medicine; Randomized controlled trial; Oncology; Internal medicine; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002287248,0.001721489,0.002705408,0.0005045449,0.0003742103,0.001275086,0.0008094685,0.001976606,0.01341933],"category_scores_gemma":[0.002247864,0.0008045952,0.002124048,0.0003945649,0.001186864,0.00136884,0.000533297,0.002444519,0.001349808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000534636,"about_ca_system_score_gemma":0.001020637,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005209831,"about_ca_topic_score_gemma":0.0006886208,"domain_scores_codex":[0.9988351,0.0006599564,0.00008118349,0.0002226549,0.00005722276,0.0001437653],"domain_scores_gemma":[0.9988604,0.0003354441,0.0003029656,0.00009373406,0.0001052804,0.0003023081],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9881591,0.003044838,0.0003611639,0.000569215,0.0009711459,0.00001456187,0.00001477238,0.0001205086,0.001601243,0.0001356089,0.000551755,0.004456199],"study_design_scores_gemma":[0.9473853,0.04970637,0.000891195,0.00003307568,0.0006056347,0.00001315426,0.00001183536,0.0003076371,0.0002443181,0.0001736261,0.00061972,0.000008164513],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663466,0.007079991,0.001601345,0.001749654,0.001821509,0.01412696,0.002943387,0.0002903016,0.004040332],"genre_scores_gemma":[0.9703823,0.001566223,0.003644421,0.001500891,0.0008086584,0.01443496,0.001658701,0.00003698593,0.005966666],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01341933,"threshold_uncertainty_score":0.04489213,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01179688764908209,"score_gpt":0.28621758925858,"score_spread":0.2744207016094979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}