{"id":"W4403512977","doi":"10.1093/neuonc/noae144.256","title":"P14.05.A A PROSPECTIVE, MULTICENTER TRIAL OF FOCUSED ULTRASOUND FOR BLOOD-BRAIN BARRIER DISRUPTION FOR LIQUID BIOPSY IN GLIOBLASTOMA (LIBERATE)","year":2024,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"Ultrasound and Hyperthermia Applications","field":"Engineering","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; Sunnybrook Health Science Centre","funders":"","keywords":"Glioblastoma; Focused ultrasound; Medicine; Blood–brain barrier; Multicenter study; Multicenter trial; Ultrasound; Biopsy; Radiology; Internal medicine; Randomized controlled trial; Cancer research; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004406875,0.001162887,0.001586943,0.0002629185,0.0003075624,0.001111301,0.0005433505,0.001202506,0.01163888],"category_scores_gemma":[0.002799093,0.0002665422,0.001508871,0.0003244983,0.0007235866,0.0009607624,0.0004329597,0.00184419,0.001015715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002854379,"about_ca_system_score_gemma":0.001145003,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001832397,"about_ca_topic_score_gemma":0.0002170549,"domain_scores_codex":[0.9979272,0.001270418,0.00009722003,0.0003598222,0.0001087015,0.0002365997],"domain_scores_gemma":[0.9979735,0.0007261338,0.000415869,0.0002192258,0.0001446631,0.0005205646],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9772006,0.002296825,0.003007727,0.0003641135,0.001141631,0.00005144477,0.00003507372,0.000241909,0.004131771,0.000229489,0.001726951,0.009572602],"study_design_scores_gemma":[0.5680903,0.3768668,0.03521374,0.000124843,0.003259559,0.0001615198,0.00007734881,0.002884014,0.005394536,0.001189603,0.006696216,0.00004152156],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.9805269,0.003761501,0.002059183,0.001355627,0.0007150355,0.003777644,0.00313379,0.0002417105,0.004428696],"genre_scores_gemma":[0.983533,0.0006816824,0.002989716,0.000872521,0.0003192959,0.004452784,0.002263116,0.00004918464,0.004838751],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.01163888,"threshold_uncertainty_score":0.03893596,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01171061866547595,"score_gpt":0.2741897330267077,"score_spread":0.2624791143612317,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}