{"id":"W4403513410","doi":"10.1136/ard-2023-225434","title":"Efficacy, safety and tolerability of GSK3858279, an anti-CCL17 monoclonal antibody and analgesic, in healthy volunteers and patients with knee osteoarthritis pain: a phase I, randomised, double-blind, placebo-controlled, proof-of-mechanism and proof-of-concept study","year":2024,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Osteoarthritis Treatment and Mechanisms","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Japanese Society of Nephrology; GlaxoSmithKline; AstraZeneca","keywords":"Medicine; Tolerability; Placebo; Osteoarthritis; Analgesic; Physical therapy; Knee pain; Internal medicine; Adverse effect; Anesthesia; Alternative medicine; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003652219,0.001205637,0.00233172,0.0003996889,0.000404527,0.0007288137,0.001031567,0.001667439,0.007220359],"category_scores_gemma":[0.001798754,0.0007436065,0.001446884,0.0003975825,0.001057827,0.001084808,0.0004069991,0.001882542,0.001095633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005726033,"about_ca_system_score_gemma":0.001597941,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002929969,"about_ca_topic_score_gemma":0.001045641,"domain_scores_codex":[0.9989448,0.0005382777,0.00009992532,0.0001101508,0.0001863735,0.0001205015],"domain_scores_gemma":[0.9988598,0.0002847087,0.0003873701,0.00007232613,0.0001485034,0.00024744],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7762316,0.03847023,0.002023292,0.007437867,0.00158965,0.0003187712,0.000324063,0.0007524975,0.09016125,0.0003567594,0.002877554,0.07945644],"study_design_scores_gemma":[0.6113016,0.3754349,0.005584083,0.0001213661,0.0006671692,0.0002643824,0.00007563979,0.000350115,0.003845032,0.00009485574,0.002226499,0.00003442807],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9771094,0.01110642,0.001553396,0.0006758331,0.0003926448,0.006431221,0.001025448,0.0001208188,0.001584866],"genre_scores_gemma":[0.9793279,0.006103169,0.003336742,0.001032397,0.0005220593,0.006295337,0.0009850555,0.00002418842,0.002373158],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007220359,"threshold_uncertainty_score":0.02415448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0225735015094313,"score_gpt":0.3136208691734702,"score_spread":0.2910473676640388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}