{"id":"W4403513715","doi":"10.1186/s40478-024-01872-2","title":"Acquisition of neurodegenerative features in isogenic OPTN(E50K) human stem cell-derived retinal ganglion cells associated with autophagy disruption and mTORC1 signaling reduction","year":2024,"lang":"en","type":"article","venue":"Acta Neuropathologica Communications","topic":"Autophagy in Disease and Therapy","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"National Eye Institute; National Center for Advancing Translational Sciences; Fonds de Recherche du Québec - Santé; Glaucoma Research Foundation; Canadian Institutes of Health Research; Indiana State Department of Health; BrightFocus Foundation; Gilbert Family Foundation","keywords":"mTORC1; Autophagy; Cell biology; Neuroscience; Stem cell; Biology; Retinal ganglion cell; Retinal; Signal transduction; Retina; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000280896,0.0001969085,0.0002845426,0.0002144898,0.0002427084,0.0000475635,0.0002059746,0.0001187474,0.00002139541],"category_scores_gemma":[0.00001868414,0.0001622828,0.00007642281,0.0004719517,0.0002518203,0.0001719245,0.0001081372,0.0004457846,0.000002360545],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000659461,"about_ca_system_score_gemma":0.00005533979,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001032601,"about_ca_topic_score_gemma":0.000003923421,"domain_scores_codex":[0.9983593,0.0005688727,0.0003485288,0.0003646569,0.0001781976,0.0001804758],"domain_scores_gemma":[0.9987887,0.0001652109,0.0001804145,0.0006806927,0.0001150081,0.00006997422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001175436,0.0003539456,0.0002912457,0.00004692411,0.00002663349,0.0001034419,0.001668437,0.0000677066,0.9965607,0.0002494348,0.00004031785,0.0004736697],"study_design_scores_gemma":[0.001468316,0.00179268,0.2106763,0.0006327001,0.0003585299,0.0002654751,0.0009602243,0.002087589,0.7811235,0.0002714341,0.00004413734,0.0003191347],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965281,0.001732108,0.0000961804,0.0005141771,0.00006358303,0.0004913175,0.00002865648,0.000136204,0.0004096544],"genre_scores_gemma":[0.9981318,0.0009648376,0.0003003422,0.0000954897,0.00004310058,0.00006497845,0.0001974221,0.0000331995,0.000168878],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2154372,"threshold_uncertainty_score":0.66177,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02374108083982478,"score_gpt":0.2855355603980641,"score_spread":0.2617944795582393,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}