{"id":"W4403519527","doi":"10.3390/biom14101307","title":"How Do ROS Induce NETosis? Oxidative DNA Damage, DNA Repair, and Chromatin Decondensation","year":2024,"lang":"en","type":"review","venue":"Biomolecules","topic":"Neutrophil, Myeloperoxidase and Oxidative Mechanisms","field":"Immunology and Microbiology","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Hospital for Sick Children","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Hospital for Sick Children; University of Toronto","keywords":"Neutrophil extracellular traps; Cell biology; DNA damage; NADPH oxidase; Reactive oxygen species; Biology; Programmed cell death; DNA repair; Chromatin; DNA; Apoptosis; Immunology; Inflammation; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006561927,0.0006000195,0.0007509231,0.0006451187,0.0004481394,0.001498053,0.0004082468,0.001462621,0.002049124],"category_scores_gemma":[0.0007902559,0.000327245,0.0006011827,0.0002811551,0.001018532,0.001935814,0.0006382309,0.001506237,0.0009378591],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006275133,"about_ca_system_score_gemma":0.0003654731,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000292393,"about_ca_topic_score_gemma":0.0004098139,"domain_scores_codex":[0.9993717,0.0001275144,0.00005774444,0.0001405265,0.0001753055,0.0001272914],"domain_scores_gemma":[0.9994134,0.00009495782,0.0001841188,0.00005271793,0.0001302396,0.0001246661],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001458377,0.0004290009,0.01437725,0.004431645,0.0003551196,0.004918971,0.0007834602,0.0009965714,0.8321214,0.02192358,0.01120513,0.1069994],"study_design_scores_gemma":[0.0002734585,0.003306188,0.07934345,0.001488677,0.0005004939,0.01944694,0.00258984,0.003589995,0.6006854,0.0533108,0.2352114,0.0002534293],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.4655673,0.4206731,0.04165547,0.02760661,0.006359646,0.0006069209,0.002170627,0.001201859,0.03415858],"genre_scores_gemma":[0.8758163,0.09512863,0.007019585,0.006386591,0.001469876,0.0001920795,0.0007597976,0.0000914747,0.01313568],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002049124,"threshold_uncertainty_score":0.006855011,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03583420143072921,"score_gpt":0.2964235352781274,"score_spread":0.2605893338473981,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}