{"id":"W4403520141","doi":"10.1158/2326-6074.tumimm24-pr-07","title":"Abstract PR-07: Optimally designed mRNA vaccine encoding tumor-specific antigens identified in a colorectal cancer model leads to complete tumor rejection in mice","year":2024,"lang":"en","type":"article","venue":"Cancer Immunology Research","topic":"Cancer Research and Treatments","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Colorectal cancer; Medicine; Antigen; Cancer; Messenger RNA; Cancer immunotherapy; Immunology; Immunotherapy; Cancer research; Gene; Immune system; Biology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001718119,0.0004315303,0.0003051063,0.000271166,0.0001023686,0.0002071771,0.0002246844,0.0004506409,0.001512678],"category_scores_gemma":[0.0001170923,0.0001418449,0.0002815803,0.0001320256,0.000237364,0.0001727645,0.0001149701,0.0008147222,0.0004149305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003139078,"about_ca_system_score_gemma":0.0002081389,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002747618,"about_ca_topic_score_gemma":0.0003728902,"domain_scores_codex":[0.9997545,0.0000319801,0.00002429354,0.00006545753,0.00005649177,0.00006727541],"domain_scores_gemma":[0.9998534,0.00002157193,0.00005549672,0.00001312375,0.00001547728,0.00004089278],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001801845,0.0001101436,0.00006695677,0.00003060872,0.000004939049,0.00001984347,0.000006023387,0.000144738,0.9987404,0.00006879261,0.00003565971,0.0005919132],"study_design_scores_gemma":[0.00004044948,0.002013913,0.0008299873,0.000006165207,0.00001818852,0.0001073345,0.00001412655,0.001158611,0.9943615,0.00002950591,0.001416024,0.00000427198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930096,0.0004599289,0.004732009,0.0001225462,0.00006313233,0.00007912009,0.0005040247,0.000118789,0.0009110176],"genre_scores_gemma":[0.9869041,0.0004284526,0.007745401,0.00009775536,0.00001806448,0.0001099452,0.001216812,0.00005457659,0.003424868],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001512678,"threshold_uncertainty_score":0.005060434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06872976233229297,"score_gpt":0.3832589657625793,"score_spread":0.3145292034302863,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}