{"id":"W4403520264","doi":"10.1093/jac/dkae333","title":"Quantitative performance of humanized serum and epithelial lining fluid exposures of tigecycline and levofloxacin against a challenge set of <i>Klebsiella pneumoniae</i> and <i>Pseudomonas aeruginosa</i> in a standardized neutropenic murine pneumonia model","year":2024,"lang":"en","type":"article","venue":"Journal of Antimicrobial Chemotherapy","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; Biomedical Advanced Research and Development Authority; Novo Nordisk Fonden; Novo Nordisk; Bundesministerium für Bildung und Forschung; Public Health Agency of Canada; Department of Health and Social Care; Wellcome Trust; Public Health Agency; Wellcome; Combating Antibiotic-Resistant Bacteria Biopharmaceutical Accelerator; Pfizer; Bill and Melinda Gates Foundation; National Institutes of Health; Shionogi; U.S. Department of Health and Human Services","keywords":"Tigecycline; Klebsiella pneumoniae; Pseudomonas aeruginosa; Levofloxacin; Microbiology; Medicine; Antibiotics; Biology; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006616684,0.000430344,0.0003009364,0.0001814548,0.0001015411,0.0003578356,0.0002703974,0.0003586504,0.0009131221],"category_scores_gemma":[0.0006681077,0.0001469104,0.0002946814,0.0001892354,0.0002568342,0.000196088,0.0002221792,0.0003797871,0.0001905519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003125473,"about_ca_system_score_gemma":0.0003540625,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001182181,"about_ca_topic_score_gemma":0.001226295,"domain_scores_codex":[0.9991804,0.0002937096,0.00007861631,0.0001376138,0.0002418338,0.00006793092],"domain_scores_gemma":[0.9995773,0.0001008059,0.0001099562,0.0000608285,0.000108231,0.00004288404],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00132943,0.0004187532,0.001753029,0.0000756459,0.0000339193,0.00002461819,0.00005903074,0.0007534316,0.9905779,0.00003073713,0.0001149803,0.004828513],"study_design_scores_gemma":[0.00004224306,0.01107841,0.008629221,0.000009702301,0.00003913269,0.0001361298,0.00005594348,0.001598601,0.977556,0.0000215341,0.0008235858,0.000009428119],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9932997,0.000693408,0.004237005,0.00005366949,0.00002623644,0.0001854122,0.0007256279,0.00005478024,0.0007240988],"genre_scores_gemma":[0.9893132,0.0005181578,0.007707802,0.00006354796,0.00001680401,0.0001566211,0.001160417,0.00001258079,0.001050961],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001182181,"threshold_uncertainty_score":0.003499269,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.012343637668726,"score_gpt":0.2633002620285146,"score_spread":0.2509566243597887,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}