{"id":"W4403526926","doi":"10.1016/j.bpj.2024.10.011","title":"A conserved H-bond network in human aquaporin-1 is necessary for native folding and oligomerization","year":2024,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Forschungszentrum Jülich; University of Guelph","keywords":"Folding (DSP implementation); Chemistry; Protein folding; Native state; Biophysics; Bond; Biology; Crystallography; Biochemistry; Business; Engineering","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001493653,0.00009217442,0.0001111421,0.00004505635,0.0001209967,0.0001014994,0.0000743235,0.00007047819,0.00001113277],"category_scores_gemma":[0.00002743975,0.00007947685,0.00007545215,0.0001239933,0.00006268931,0.000009633596,0.00005408911,0.0001379889,0.000001603521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001361509,"about_ca_system_score_gemma":0.00005538015,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000006597599,"about_ca_topic_score_gemma":0.000003357609,"domain_scores_codex":[0.9992967,0.00003470129,0.000151098,0.000199181,0.00009956826,0.000218706],"domain_scores_gemma":[0.9997457,0.00003657648,0.00003082045,0.00006401263,0.00004087328,0.00008200693],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005654546,0.00003061654,0.0004923273,0.00003343799,0.0000498175,0.00002261589,0.00005623555,0.00001331984,0.9938278,0.0007431087,0.002115905,0.002558253],"study_design_scores_gemma":[0.001169702,0.0008243409,0.002216431,0.0002598707,0.00003659146,0.0000417383,0.0002135993,0.005659688,0.9690269,0.002924511,0.01727244,0.0003542246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953002,0.0006641751,0.003232821,0.000428671,0.00008983767,0.0001188223,0.00001690098,0.000005675819,0.0001428515],"genre_scores_gemma":[0.9980117,0.0002349859,0.000269878,0.0001294923,0.001122885,0.00001330476,0.0000293648,0.00001640205,0.0001719813],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02480096,"threshold_uncertainty_score":0.3240972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02378267274767356,"score_gpt":0.3323436271574122,"score_spread":0.3085609544097387,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}