{"id":"W4403537638","doi":"10.1016/j.esmoop.2024.103754","title":"8P Precision medicine drug testing platform to guide the treatment of EML4-ALK fusion lung cancers","year":2024,"lang":"en","type":"article","venue":"ESMO Open","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Precision medicine; Drug; Lung; Oncology; Medical physics; Internal medicine; Pharmacology; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002097651,0.0001491639,0.0002775919,0.0000897604,0.0001479794,0.00004193344,0.0001719439,0.00003049317,0.0004463203],"category_scores_gemma":[0.00008795699,0.00007434798,0.00005320552,0.0004035773,0.00004236713,0.0001148167,0.00007728076,0.00005764205,0.00003452626],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009447795,"about_ca_system_score_gemma":0.0004545253,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02998888,"about_ca_topic_score_gemma":0.001517361,"domain_scores_codex":[0.9989672,0.0000158534,0.000305883,0.0002761539,0.0002604088,0.0001745022],"domain_scores_gemma":[0.9991,0.0002851695,0.00005446222,0.0003509664,0.00009212153,0.0001172768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003409077,0.0002755559,0.007953586,0.0001605398,0.0007863356,0.0001735069,0.03463694,0.0004392786,0.001403031,0.0007351352,0.2017733,0.7513219],"study_design_scores_gemma":[0.003694351,0.002491109,0.02859557,0.003236886,0.001342693,0.00005930196,0.002902834,0.00321308,0.004337979,0.0003509712,0.9495685,0.0002067791],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.5940246,0.006681041,0.0003910554,0.03742801,0.002069887,0.0073375,0.00009132573,0.000178648,0.3517979],"genre_scores_gemma":[0.9494019,0.0005358772,0.002893325,0.000896203,0.0004727079,0.0004044817,0.00009654153,0.00004448157,0.04525447],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7511151,"threshold_uncertainty_score":0.9764705,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04747564389814995,"score_gpt":0.4132002471207954,"score_spread":0.3657246032226454,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}