{"id":"W4403539785","doi":"10.1038/s41418-024-01382-7","title":"Editorial Expression of Concern: The NAD+ salvage pathway modulates cancer cell viability via p73","year":2024,"lang":"en","type":"article","venue":"Cell Death and Differentiation","topic":"Calcium signaling and nucleotide metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta; Izaak Walton Killam Health Centre; Dalhousie University","funders":"","keywords":"NAD+ kinase; Viability assay; Chemistry; Cancer research; Cell biology; Cancer; Cell; Biology; Biochemistry; Enzyme; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001285603,0.0001140563,0.0001115043,0.00001351053,0.00007095774,0.00003905195,0.00007339077,0.000122762,0.00003396305],"category_scores_gemma":[0.00001339951,0.00007652365,0.0000764084,0.00003307564,0.00003899688,0.000006668273,0.00005515283,0.00007419071,0.000001638371],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000009000283,"about_ca_system_score_gemma":0.0000325453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001557424,"about_ca_topic_score_gemma":0.00001297099,"domain_scores_codex":[0.9992768,0.00006358248,0.0001614336,0.0002519173,0.0001271203,0.0001191398],"domain_scores_gemma":[0.999635,0.00002887051,0.00005570608,0.0001777004,0.00005536949,0.00004738648],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004230251,0.0000340639,0.0009305762,0.0001020653,0.000008131316,1.460867e-7,0.0001214491,0.00002608699,0.9948372,0.00002469284,0.002596876,0.001276443],"study_design_scores_gemma":[0.0002795108,0.00005276231,0.002603946,0.00002029115,0.00003992032,2.823419e-7,0.00002088755,0.0009255529,0.9837759,0.0003480017,0.01183443,0.00009856272],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9764621,0.01181382,0.001614854,0.00002063953,0.00969902,0.0001358667,0.00004297953,0.00001494593,0.0001957652],"genre_scores_gemma":[0.9893899,0.0006651528,0.00002658723,0.00001922178,0.009568527,0.00001590425,0.00009562592,0.00001313164,0.0002059482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01292779,"threshold_uncertainty_score":0.3120544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008219636940808774,"score_gpt":0.2320257202230147,"score_spread":0.2238060832822059,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}