{"id":"W4403540892","doi":"10.1016/j.scr.2024.103583","title":"Ice recrystallization inhibitors enable efficient cryopreservation of induced pluripotent stem cells: A functional and transcriptomic analysis","year":2024,"lang":"en","type":"article","venue":"Stem Cell Research","topic":"Reproductive Biology and Fertility","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; Emergent BioSolutions (Canada)","funders":"","keywords":"Biology; Cryopreservation; Induced pluripotent stem cell; Transcriptome; Stem cell; Cell biology; Recrystallization (geology); Computational biology; Embryonic stem cell; Biochemistry; Gene; Embryo; Gene expression","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002146136,0.0001137396,0.0002692653,0.0006445489,0.000119514,0.00003060262,0.00006687001,0.0001588358,0.00009189399],"category_scores_gemma":[0.00002263593,0.0000910971,0.0001191338,0.001678081,0.0001601982,0.00007900276,0.00005244614,0.0003846209,0.00001304546],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001629177,"about_ca_system_score_gemma":0.0002245969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001360562,"about_ca_topic_score_gemma":0.00001719903,"domain_scores_codex":[0.9978071,0.0003681777,0.0003591895,0.0005923922,0.0006059331,0.0002671765],"domain_scores_gemma":[0.9987864,0.0002028715,0.0000417301,0.0003445057,0.0005159205,0.0001085952],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001602579,0.0002256398,0.005611861,0.000955465,0.0003296186,0.000009711916,0.001121067,0.0006060169,0.9856948,0.0001113803,0.0003432604,0.003388568],"study_design_scores_gemma":[0.0007266646,0.0006322278,0.05738974,0.0001686242,0.000419139,0.000004830809,0.002343712,0.03029749,0.9050308,0.0001237703,0.002713506,0.0001494575],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930742,0.002992213,0.001577511,0.000342483,0.0002231792,0.0006487299,0.00001243781,0.0000387787,0.001090457],"genre_scores_gemma":[0.9965522,0.000123331,0.00002944688,0.000008106303,0.0001070001,0.00003815674,0.00003271837,0.00001306593,0.003095942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.080664,"threshold_uncertainty_score":0.3714832,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09333147556349158,"score_gpt":0.3257660355108876,"score_spread":0.232434559947396,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}