{"id":"W4403541035","doi":"10.1016/j.jacig.2024.100353","title":"Omics analysis reveals galectin-3 to be a potential key regulator of allergic inflammation in hereditary angioedema","year":2024,"lang":"en","type":"article","venue":"Journal of Allergy and Clinical Immunology Global","topic":"Coagulation, Bradykinin, Polyphosphates, and Angioedema","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Takeda Canada; Stony Brook University; Takeda Pharmaceutical Company","keywords":"Hereditary angioedema; Regulator; Inflammation; Key (lock); Allergic inflammation; Galectin; Angioedema; Medicine; Immunology; Computational biology; Biology; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004920416,0.0007048132,0.0006600617,0.00191296,0.0003901827,0.001030838,0.0002745505,0.0004612513,0.001803231],"category_scores_gemma":[0.0004989357,0.0001367629,0.001015287,0.002215169,0.000226978,0.0004037203,0.0006536461,0.0004725759,0.0005410967],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006405376,"about_ca_system_score_gemma":0.0004119961,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006483556,"about_ca_topic_score_gemma":0.0008813743,"domain_scores_codex":[0.9996006,0.00004657115,0.00003297678,0.0001164106,0.0001364098,0.00006701572],"domain_scores_gemma":[0.9997177,0.00006896323,0.0001094497,0.00002552421,0.0000411248,0.00003733196],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001403659,0.0001520194,0.1739323,0.001088058,0.0007225857,0.001464093,0.000204198,0.003234034,0.7571363,0.001304643,0.004056285,0.05530175],"study_design_scores_gemma":[0.000117469,0.0006545351,0.7341441,0.0002774557,0.001261618,0.004903988,0.0005779742,0.03778061,0.1656029,0.006607541,0.04797375,0.0000981363],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9319884,0.008428689,0.01825142,0.001209567,0.00009746291,0.0001198022,0.03416139,0.001005972,0.004737341],"genre_scores_gemma":[0.9347098,0.002990585,0.02514466,0.0009197691,0.00005761419,0.0001046895,0.03473382,0.0001064003,0.001232604],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00191296,"threshold_uncertainty_score":0.006032348,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01914293399233232,"score_gpt":0.3242558127421581,"score_spread":0.3051128787498258,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}