{"id":"W4403541538","doi":"10.1016/j.ceca.2024.102961","title":"ER stress as a sentinel mechanism for ER Ca2+ homeostasis","year":2024,"lang":"no","type":"review","venue":"Cell Calcium","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":69,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Mechanism (biology); Homeostasis; Stress (linguistics); Cell biology; Chemistry; Biophysics; Biology; Physics; Philosophy","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0002001012,0.001228365,0.00145172,0.0001644764,0.0002039855,0.0002752542,0.0006819711,0.001224353,0.000346147],"category_scores_gemma":[0.0001578862,0.001034481,0.002139765,0.0002311943,0.0001566314,0.000006299772,0.000588643,0.0004872025,0.0008720838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008408052,"about_ca_system_score_gemma":0.0008836657,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000536724,"about_ca_topic_score_gemma":0.000006925537,"domain_scores_codex":[0.9955745,0.000158252,0.0009625968,0.00181063,0.0004039275,0.001090065],"domain_scores_gemma":[0.9972681,0.00007081257,0.0004040721,0.001251089,0.0003451389,0.0006608206],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0008844622,0.003601116,0.0000915319,0.4083314,0.007001834,0.002293447,0.0003935779,0.00003943373,0.02954729,0.01453315,0.4141845,0.1190983],"study_design_scores_gemma":[0.00118046,0.0003018788,9.602487e-7,0.003289547,0.00612746,0.00006049016,0.0001837555,0.0001253682,0.0506486,0.0004003227,0.9360958,0.001585337],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.002283306,0.9773955,0.0008044392,0.0001726551,0.002416693,0.001905724,0.004983873,0.0000510608,0.009986695],"genre_scores_gemma":[0.02110254,0.9361168,0.0001844382,0.0005315158,0.002129645,0.0008904351,0.005952097,0.0003380706,0.03275443],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.5219113,"threshold_uncertainty_score":0.9999058,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02586518097709433,"score_gpt":0.3138472486398826,"score_spread":0.2879820676627883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}