{"id":"W4403543935","doi":"10.1038/s41409-024-02444-7","title":"Measurable residual FLT3 tyrosine kinase domain mutations before allogeneic transplant for acute myeloid leukemia","year":2024,"lang":"en","type":"letter","venue":"Bone Marrow Transplantation","topic":"Acute Myeloid Leukemia Research","field":"Medicine","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Cancer Research","funders":"National Institute of Environmental Health Sciences; National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Heart, Lung, and Blood Institute; U.S. Navy; Health Resources and Services Administration; Syndax Pharmaceuticals; Office of Naval Research; Jazz Pharmaceuticals; Genentech; AstraZeneca; National Institutes of Health; U.S. Department of Health and Human Services; Foundation for the National Institutes of Health; Amgen; Gilead Sciences; U.S. Department of Defense","keywords":"Medicine; Myeloid leukemia; Tyrosine kinase; Fms-Like Tyrosine Kinase 3; Cancer research; Tyrosine-kinase inhibitor; Leukemia; Mutation; CD135; Myeloid; Transplantation; Immunology; Internal medicine; Gene; Cancer; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002248064,0.0001354173,0.0002284546,0.0002381011,0.0002862088,0.0002895333,0.0001357157,0.0002038936,0.0009649644],"category_scores_gemma":[0.0006267695,0.00006929964,0.0001220151,0.0001896416,0.000150405,0.0001979477,0.0001890293,0.0004357888,0.0002060868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002361441,"about_ca_system_score_gemma":0.0003455527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009438247,"about_ca_topic_score_gemma":0.00240598,"domain_scores_codex":[0.9998622,0.00001843522,0.0000129016,0.00003808165,0.000040199,0.00002818175],"domain_scores_gemma":[0.9997616,0.00005512925,0.00008379897,0.00001176787,0.00001947093,0.00006826589],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001300938,0.0003357246,0.9193453,0.00008207473,0.00002722689,0.004649631,0.0004341314,0.0003789799,0.03748799,0.0001558774,0.0008740089,0.03492815],"study_design_scores_gemma":[0.00003341848,0.003537805,0.9758431,0.00003569806,0.00004229401,0.008527044,0.0002410264,0.0011765,0.007227046,0.0002286087,0.003092214,0.00001532363],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997926,0.0005290498,0.0005236806,0.00008088558,0.000009951521,0.00004058019,0.0002865336,0.00002292202,0.0005803298],"genre_scores_gemma":[0.9985377,0.000180185,0.0005751798,0.0001025041,0.00001389791,0.00001447124,0.0004032316,0.000004340441,0.0001684742],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009649644,"threshold_uncertainty_score":0.003228128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02039674235388189,"score_gpt":0.2848752562052676,"score_spread":0.2644785138513857,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}