{"id":"W4403568488","doi":"10.1016/j.htct.2024.09.944","title":"GENETIC AND NON-GENETIC DETERMINANTS OF SUCCESSFUL IMMUNE TOLERANCE INDUCTION IN PEOPLE WITH SEVERE HEMOPHILIA A","year":2024,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Centre Hospitalier Universitaire Sainte-Justine; McMaster University; Queen's University; Hospital for Sick Children","funders":"","keywords":"Medicine; Immune system; Immune tolerance; Immunology; Genetic diagnosis; Computational biology; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007886508,0.000152315,0.0004126283,0.0001780169,0.00004809959,0.00001058347,0.00003840957,0.00013945,0.00010595],"category_scores_gemma":[0.000001239868,0.000101614,0.00003768552,0.0002648846,0.0001337941,0.00004027978,0.000008742416,0.0001707108,0.000002945006],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000106855,"about_ca_system_score_gemma":0.00007515445,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001805723,"about_ca_topic_score_gemma":0.0002463645,"domain_scores_codex":[0.9990779,0.0000425407,0.0002422382,0.0003047502,0.0001313766,0.0002012598],"domain_scores_gemma":[0.999684,0.00004546091,0.00002225299,0.0001440689,0.00002848963,0.00007568586],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001038386,0.0002997994,0.8693703,0.001087333,0.00003709137,0.0004318399,0.002624156,0.000002549428,0.06530198,0.000007608724,0.000007358939,0.05979162],"study_design_scores_gemma":[0.005078563,0.001282876,0.8718022,0.0005921228,0.00004243455,0.002398875,0.0003329001,0.001181345,0.1169099,0.00008070937,0.0001278945,0.0001701865],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9838532,0.01491623,0.00003096471,0.0003909429,0.00005716514,0.0005206932,0.000001935539,0.0000184514,0.0002104505],"genre_scores_gemma":[0.9720172,0.02734373,0.0002442997,0.00003127894,0.00001642387,0.00003740384,0.0000022934,0.00001972947,0.0002876314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05962143,"threshold_uncertainty_score":0.4143699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01107195582513129,"score_gpt":0.2659603653752765,"score_spread":0.2548884095501452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}