{"id":"W4403568488","doi":"10.1016/j.htct.2024.09.944","title":"GENETIC AND NON-GENETIC DETERMINANTS OF SUCCESSFUL IMMUNE TOLERANCE INDUCTION IN PEOPLE WITH SEVERE HEMOPHILIA A","year":2024,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; Centre Hospitalier Universitaire Sainte-Justine; McMaster University; Queen's University; Hospital for Sick Children","funders":"","keywords":"Medicine; Immune system; Immune tolerance; Immunology; Genetic diagnosis; Computational biology; Genetics; Gene; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008558423,0.0004339189,0.000448093,0.0005658665,0.0003467407,0.0005494003,0.0003666668,0.0005123246,0.001560072],"category_scores_gemma":[0.002961191,0.0002749804,0.0007966085,0.001340333,0.0003857459,0.0002594015,0.0003426139,0.0006048959,0.0001789418],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004419296,"about_ca_system_score_gemma":0.000596297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.05064126,"about_ca_topic_score_gemma":0.03982409,"domain_scores_codex":[0.999667,0.0001062808,0.00003032026,0.00008575837,0.00004664034,0.00006404924],"domain_scores_gemma":[0.998882,0.0003124414,0.0004523497,0.00009581284,0.00009719776,0.0001601616],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002620394,0.00001837658,0.9966663,0.00002541907,0.0001360672,0.00008570096,0.00007676113,0.0001492902,0.00005152093,0.00006047461,0.0001245095,0.002343573],"study_design_scores_gemma":[0.00001755941,0.000114886,0.9979868,0.0000305008,0.0001706635,0.0002727296,0.0001550679,0.0008619784,0.00002715401,0.0001195231,0.0002376548,0.000005514031],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983778,0.0007222402,0.0001069694,0.00007859137,0.000004923582,0.000006514078,0.0002732865,0.000002459495,0.000427256],"genre_scores_gemma":[0.99943,0.0001964063,0.00005632278,0.00001170924,0.000004974222,0.000004121762,0.0002071894,0.000001078387,0.00008812302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05064126,"threshold_uncertainty_score":0.100693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01107195582513129,"score_gpt":0.2659603653752765,"score_spread":0.2548884095501452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}