{"id":"W4403568737","doi":"10.1016/j.htct.2024.09.947","title":"LARGE DELETIONS IN THE F8 GENE PREDICT IMMUNE TOLERANCE INDUCTION FAILURE IN PEOPLE WITH SEVERE HEMOPHILIA A","year":2024,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Queen's University; Hospital for Sick Children","funders":"","keywords":"Medicine; Gene; Immune system; Immune tolerance; Immunology; Genetics; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006404787,0.0003732136,0.0003203163,0.0004740992,0.0003353597,0.0004646947,0.000330132,0.0006406356,0.001963799],"category_scores_gemma":[0.0023702,0.0002631671,0.0005333859,0.000541906,0.0002779316,0.0003437815,0.0003076688,0.000597343,0.0002600309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001267367,"about_ca_system_score_gemma":0.0001803933,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00170137,"about_ca_topic_score_gemma":0.001368794,"domain_scores_codex":[0.9996824,0.0001138797,0.00003743267,0.00008105082,0.0000407539,0.00004446881],"domain_scores_gemma":[0.9987388,0.0003529908,0.0005914303,0.00008019153,0.00007539062,0.0001612112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001720907,0.00002164732,0.9985196,0.000007205476,0.00004242307,0.00007239064,0.0000300568,0.00003031057,0.0001245935,0.00001194392,0.00006183438,0.0009059119],"study_design_scores_gemma":[0.00001478337,0.0001507766,0.9983343,0.0000112883,0.00007310226,0.0005707598,0.0001306325,0.0004689124,0.00006098406,0.00005215393,0.000128452,0.000003823474],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9994147,0.0002512559,0.00006244384,0.00004334034,0.000004863643,0.000002775881,0.00006421789,0.000002085783,0.0001543049],"genre_scores_gemma":[0.9997445,0.00005985731,0.00004558314,0.00001373344,0.000008076769,0.000002257494,0.00005471996,8.487705e-7,0.00007029224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001963799,"threshold_uncertainty_score":0.006569564,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01218468361488764,"score_gpt":0.2610510433964746,"score_spread":0.2488663597815869,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}