{"id":"W4403569308","doi":"10.1016/j.htct.2024.09.055","title":"ENERGIZE: A GLOBAL PHASE 3 STUDY OF MITAPIVAT DEMONSTRATING EFFICACY AND SAFETY IN ADULTS WITH ALPHA- OR BETA-NON–TRANSFUSION-DEPENDENT THALASSEMIA","year":2024,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; BETA (programming language); Alpha (finance); Beta thalassemia; Thalassemia; Intensive care medicine; Internal medicine; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002083024,0.0002991141,0.0006718199,0.0001307282,0.0001130108,0.00001663905,0.00006389309,0.0002693032,0.000161346],"category_scores_gemma":[0.000004324207,0.0001829362,0.00006187604,0.0004110238,0.0001629842,0.00006095615,0.00001295112,0.0003578379,0.000001240883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002010074,"about_ca_system_score_gemma":0.0001327538,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003192009,"about_ca_topic_score_gemma":0.0005909225,"domain_scores_codex":[0.9982657,0.0001089185,0.0005386627,0.0005499577,0.0002361393,0.0003006362],"domain_scores_gemma":[0.9994174,0.000143049,0.00004964626,0.0001917485,0.00003728951,0.0001609197],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.1101706,0.02504695,0.2602408,0.004650752,0.001409121,0.008378822,0.06609999,0.00006692127,0.08053324,0.001116449,0.0001863281,0.4421],"study_design_scores_gemma":[0.5793754,0.07495856,0.09295262,0.01361243,0.001980299,0.0141334,0.1386338,0.007249704,0.07156482,0.0002228071,0.002515136,0.002801057],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9867982,0.009803272,0.0002356259,0.0006891852,0.00009419927,0.001375376,0.00001035404,0.00006323126,0.0009305557],"genre_scores_gemma":[0.9671099,0.03251253,0.0001326048,0.0001025905,0.00001231285,0.00003299036,0.000009040915,0.00002604657,0.00006204312],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4692048,"threshold_uncertainty_score":0.7459923,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008989807767580151,"score_gpt":0.2728364135226176,"score_spread":0.2638466057550374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}