{"id":"W4403569308","doi":"10.1016/j.htct.2024.09.055","title":"ENERGIZE: A GLOBAL PHASE 3 STUDY OF MITAPIVAT DEMONSTRATING EFFICACY AND SAFETY IN ADULTS WITH ALPHA- OR BETA-NON–TRANSFUSION-DEPENDENT THALASSEMIA","year":2024,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; BETA (programming language); Alpha (finance); Beta thalassemia; Thalassemia; Intensive care medicine; Internal medicine; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001007797,0.001192422,0.001604189,0.0003570773,0.000322945,0.0008758549,0.000612837,0.001284405,0.006917744],"category_scores_gemma":[0.0007877906,0.0004447385,0.001695576,0.0003237913,0.0006533082,0.0009458029,0.000399519,0.002812316,0.0009904116],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004562596,"about_ca_system_score_gemma":0.0007331012,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006757114,"about_ca_topic_score_gemma":0.002422257,"domain_scores_codex":[0.9997998,0.00008520942,0.000009878627,0.00004451799,0.00001864635,0.00004206189],"domain_scores_gemma":[0.9996685,0.0000740696,0.00009083925,0.0000223121,0.00003492542,0.0001093936],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8574898,0.01905028,0.002488709,0.003600558,0.003045661,0.0001685568,0.0001993729,0.001081666,0.01636532,0.0005529771,0.008830685,0.08712634],"study_design_scores_gemma":[0.8943318,0.0941333,0.005285186,0.0001964433,0.001055373,0.0001617431,0.00006891391,0.0004863871,0.001036422,0.0002996043,0.002916181,0.00002866358],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.958188,0.02117672,0.00143119,0.001694421,0.0005379631,0.005533183,0.003709691,0.0004962938,0.007232543],"genre_scores_gemma":[0.969394,0.01078203,0.002441456,0.003679881,0.0003837623,0.004824623,0.00355045,0.00008724881,0.004856582],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006917744,"threshold_uncertainty_score":0.02314216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008989807767580151,"score_gpt":0.2728364135226176,"score_spread":0.2638466057550374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}