{"id":"W4403569520","doi":"10.1016/j.htct.2024.09.057","title":"IMPROVEMENTS IN FATIGUE AND 6-MINUTE WALK TEST IN ADULTS WITH ALPHA- OR BETA-NON–TRANSFUSION-DEPENDENT THALASSEMIA: THE PHASE 3 ENERGIZE TRIAL OF MITAPIVAT","year":2024,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Alpha (finance); BETA (programming language); Beta thalassemia; Test (biology); Thalassemia; Physical therapy; Internal medicine; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001005814,0.001198912,0.001954723,0.0002554956,0.0003216196,0.0006215785,0.0004383372,0.001014937,0.003078286],"category_scores_gemma":[0.0006495345,0.0004694679,0.001666607,0.0002117347,0.0004587887,0.0005286154,0.0002977159,0.001948248,0.0003747342],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003392693,"about_ca_system_score_gemma":0.000498867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007724639,"about_ca_topic_score_gemma":0.00202295,"domain_scores_codex":[0.9998071,0.00008851886,0.00001381051,0.00003187856,0.00001598896,0.00004276478],"domain_scores_gemma":[0.9996959,0.00005954774,0.00008837896,0.0000180445,0.00003065016,0.0001074628],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9523852,0.01107155,0.002930377,0.001034657,0.00158696,0.00005713174,0.00008433906,0.0004051533,0.005289833,0.00009013501,0.001284441,0.02378019],"study_design_scores_gemma":[0.8470735,0.1355183,0.01396889,0.00009344734,0.001114977,0.00007825941,0.00004451358,0.0005472208,0.0006663866,0.0001168176,0.0007588234,0.00001888584],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9910961,0.004979878,0.0002209472,0.0003761268,0.0002095159,0.001281744,0.0006027119,0.00006061569,0.001172437],"genre_scores_gemma":[0.9915686,0.002601492,0.0005534297,0.0008420265,0.0002521855,0.001926425,0.0008286354,0.000009186549,0.001418118],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003078286,"threshold_uncertainty_score":0.01029789,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212543150610066,"score_gpt":0.267642548107346,"score_spread":0.2555171166012453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}