{"id":"W4403569520","doi":"10.1016/j.htct.2024.09.057","title":"IMPROVEMENTS IN FATIGUE AND 6-MINUTE WALK TEST IN ADULTS WITH ALPHA- OR BETA-NON–TRANSFUSION-DEPENDENT THALASSEMIA: THE PHASE 3 ENERGIZE TRIAL OF MITAPIVAT","year":2024,"lang":"en","type":"article","venue":"Hematology Transfusion and Cell Therapy","topic":"Hemoglobinopathies and Related Disorders","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Medicine; Alpha (finance); BETA (programming language); Beta thalassemia; Test (biology); Thalassemia; Physical therapy; Internal medicine; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002875016,0.0002674561,0.0005777022,0.0002022218,0.00007025053,0.00001505521,0.00008181537,0.0003073429,0.0001649184],"category_scores_gemma":[0.000007322263,0.0001374292,0.00007499021,0.0003485366,0.0002054345,0.00006211492,0.00001298418,0.0004611821,0.000001050797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001668792,"about_ca_system_score_gemma":0.000141998,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005204214,"about_ca_topic_score_gemma":0.0007980852,"domain_scores_codex":[0.9984314,0.00008035676,0.0005204692,0.0004469033,0.0002228871,0.0002979143],"domain_scores_gemma":[0.9993355,0.0002728612,0.00005135483,0.0002116928,0.00002847323,0.0001001742],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2897714,0.01206251,0.04423929,0.003835749,0.0005242238,0.003301942,0.03677066,0.00001075219,0.2984172,0.0004417797,0.0004914661,0.310133],"study_design_scores_gemma":[0.7186363,0.0238744,0.004608986,0.004817503,0.0003989721,0.00126123,0.01362062,0.002659242,0.2257214,0.0002666721,0.003200096,0.0009346313],"study_design_candidate":"randomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9871737,0.008068085,0.00009390579,0.002223868,0.000166314,0.001618108,0.00001209853,0.00002788983,0.0006160818],"genre_scores_gemma":[0.9186994,0.08059353,0.00005381231,0.0002424062,0.00001847085,0.0001033539,0.00001245171,0.00002888166,0.0002477155],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4288648,"threshold_uncertainty_score":0.5604199,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01212543150610066,"score_gpt":0.267642548107346,"score_spread":0.2555171166012453,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}