{"id":"W4403571486","doi":"10.1101/2024.10.18.618978","title":"Discovery of broad-spectrum bacterial polyamine detoxification inhibitors as potential antivirulence agents and antibiotic adjuvants","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Women and Children’s Health Research Institute; University of Alberta; Alberta Biodiversity Monitoring Institute; Western University; University of Regina","funders":"","keywords":"Broad spectrum; Detoxification (alternative medicine); Antibiotics; Microbiology; Polyamine; Chemistry; Computational biology; Biology; Combinatorial chemistry; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002288468,0.000446461,0.0004282683,0.0001830266,0.00008752303,0.0001743136,0.0003857168,0.0004644549,0.000006924684],"category_scores_gemma":[0.00009219614,0.0004698317,0.0001484942,0.0002453468,0.0002340532,0.00001919384,0.0009576271,0.0003148819,0.00002604168],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002807914,"about_ca_system_score_gemma":0.000351606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008184939,"about_ca_topic_score_gemma":0.000002993777,"domain_scores_codex":[0.9977357,0.00008094791,0.0005190498,0.001045323,0.000247314,0.0003716849],"domain_scores_gemma":[0.9983861,0.000009235153,0.0003604539,0.0009922637,0.0001164328,0.0001354703],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004624798,0.0001227806,0.001185211,0.0002790511,0.0001177322,0.000008219478,0.000003613838,0.000004842695,0.9976615,0.0003307516,0.0002228064,0.00001721552],"study_design_scores_gemma":[0.0003179454,0.00006254993,0.08170684,0.0002076724,0.0001711816,1.106485e-7,0.000002408134,0.00007234301,0.9158987,0.00001188037,0.001108306,0.0004400028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925627,0.003743191,0.0006248807,0.0001575107,0.001420178,0.0005199717,0.0009061248,0.00005593236,0.000009524117],"genre_scores_gemma":[0.9960806,0.002108891,0.000492839,0.00004892592,0.001094561,0.00003912086,0.00001145431,0.00009233117,0.00003126833],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08176276,"threshold_uncertainty_score":0.9997754,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006980839800327427,"score_gpt":0.2232646596872783,"score_spread":0.2162838198869509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}