{"id":"W4403599987","doi":"10.1016/j.biomaterials.2024.122908","title":"Electrically-driven drug delivery into deep cutaneous tissue by conductive microneedles for fungal infection eradication and protective immunity","year":2024,"lang":"en","type":"article","venue":"Biomaterials","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Health and Health Services Research Fund; Shenzhen and Hong Kong Joint Innovation Project; General Research Fund of Shanghai Normal University; Food and Health Bureau; Bulgarian National Science Fund; Basic and Applied Basic Research Foundation of Guangdong Province; Research Grants Council, University Grants Committee; Hong Kong Government; National Natural Science Foundation of China; Science, Technology and Innovation Commission of Shenzhen Municipality; City University of Hong Kong","keywords":"Materials science; Drug delivery; Immunity; Electrical conductor; Drug; Electrically conductive; Biomedical engineering; Nanotechnology; Composite material; Immunology; Immune system; Medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003893895,0.0002589392,0.0002770956,0.0001456651,0.0003756351,0.00008156729,0.0001283018,0.0002818408,0.0002133627],"category_scores_gemma":[0.00006124056,0.000256476,0.00005254742,0.0001633607,0.0002607169,0.0002833447,0.00005625909,0.0001179978,0.00006036654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002383807,"about_ca_system_score_gemma":0.0000673141,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002582365,"about_ca_topic_score_gemma":0.00003351365,"domain_scores_codex":[0.9982663,0.0004766532,0.0003657386,0.0004283725,0.00009733954,0.0003656125],"domain_scores_gemma":[0.999138,0.0003939687,0.0001079247,0.0001230621,0.0001212563,0.0001157731],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006092087,0.0001399299,0.00008713747,0.0002953302,0.0003222829,0.00001676871,0.001517449,0.00002703789,0.9645769,0.0001372462,0.001402681,0.03086806],"study_design_scores_gemma":[0.0006241456,0.0002804443,0.0001100006,0.00003227068,0.0002194915,0.00009833532,0.00007175247,0.001394836,0.9514984,0.001614861,0.04376322,0.0002921897],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9815273,0.003971684,0.01001551,0.0003111894,0.001551664,0.00194232,0.0003726266,0.0002507253,0.00005702572],"genre_scores_gemma":[0.996098,0.001065802,0.001451081,0.000204364,0.0002110965,0.0005726781,0.0002094609,0.00004264777,0.000144904],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04236054,"threshold_uncertainty_score":0.9999887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04023572754384766,"score_gpt":0.394564117235757,"score_spread":0.3543283896919093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}