{"id":"W4403599987","doi":"10.1016/j.biomaterials.2024.122908","title":"Electrically-driven drug delivery into deep cutaneous tissue by conductive microneedles for fungal infection eradication and protective immunity","year":2024,"lang":"en","type":"article","venue":"Biomaterials","topic":"Advancements in Transdermal Drug Delivery","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Alberta","funders":"Health and Health Services Research Fund; Shenzhen and Hong Kong Joint Innovation Project; General Research Fund of Shanghai Normal University; Food and Health Bureau; Bulgarian National Science Fund; Basic and Applied Basic Research Foundation of Guangdong Province; Research Grants Council, University Grants Committee; Hong Kong Government; National Natural Science Foundation of China; Science, Technology and Innovation Commission of Shenzhen Municipality; City University of Hong Kong","keywords":"Materials science; Drug delivery; Immunity; Electrical conductor; Drug; Electrically conductive; Biomedical engineering; Nanotechnology; Composite material; Immunology; Immune system; Medicine; Pharmacology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001306135,0.0001899116,0.0001074975,0.0001254021,0.00008845158,0.0002319333,0.0001192218,0.0002832723,0.0006066071],"category_scores_gemma":[0.0001182531,0.00006670202,0.0001447909,0.00007513957,0.0001515278,0.0002912906,0.0002078823,0.0003170566,0.0001464306],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001521852,"about_ca_system_score_gemma":0.0001076489,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001071702,"about_ca_topic_score_gemma":0.0003196903,"domain_scores_codex":[0.9999282,0.00001141595,0.000004477824,0.00001704077,0.00002173162,0.0000170252],"domain_scores_gemma":[0.9999465,0.00001637394,0.00001607961,0.000004529818,0.000007798831,0.000008832371],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001740392,0.00001115884,0.00002452114,0.00004510098,0.000001605617,0.00002032955,0.00001001706,0.00005204788,0.9953935,0.0001751993,0.00003831461,0.004210663],"study_design_scores_gemma":[0.000007743544,0.000218098,0.0008850894,0.00001002521,0.000009130915,0.0001298161,0.0000223428,0.00120006,0.9946708,0.0001081835,0.002733842,0.00000493084],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9356328,0.01411577,0.04409073,0.000442771,0.0002228803,0.0000833516,0.0001004154,0.0002073101,0.00510384],"genre_scores_gemma":[0.9854763,0.002715493,0.008881347,0.0001794852,0.000028551,0.00004226762,0.00002604204,0.0000124642,0.002637935],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006066071,"threshold_uncertainty_score":0.00202924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04023572754384766,"score_gpt":0.394564117235757,"score_spread":0.3543283896919093,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}