{"id":"W4403604899","doi":"10.58931/cot.2024.1222","title":"From Intractable to Treatable: Milestones and Horizons in the Management of HER2+ Breast Cancer","year":2024,"lang":"en","type":"article","venue":"Canadian oncology today.","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"","keywords":"Breast cancer; Medicine; New horizons; Cancer; General surgery; Internal medicine; Engineering","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003508559,0.0001153425,0.0002636514,0.0002994816,0.00004694483,0.00002539959,0.0001762132,0.0001200608,0.001282819],"category_scores_gemma":[0.00001362462,0.00008796586,0.00002630317,0.0005880351,0.0001228056,0.00004541713,0.00003990989,0.0002991034,0.00004805498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001235421,"about_ca_system_score_gemma":0.001848767,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.5588971,"about_ca_topic_score_gemma":0.6270247,"domain_scores_codex":[0.9988142,0.00007454814,0.0001934422,0.0003087377,0.000171854,0.0004371994],"domain_scores_gemma":[0.9991122,0.0001456359,0.00001494212,0.0002945751,0.00004122237,0.0003914254],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000176816,0.0001191656,0.02755822,0.0005611852,0.0003827695,0.006050378,0.004917508,0.00001692334,0.0006117059,0.002112479,0.2517593,0.7057335],"study_design_scores_gemma":[0.0006143341,0.0003248989,0.194177,0.0008671485,0.0001440687,0.0001828443,0.002877842,0.00009093031,0.0001205043,0.0002555275,0.8002143,0.000130618],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8221537,0.009070018,0.000008639941,0.1286988,0.0006870753,0.001180245,0.001100103,0.0000284633,0.03707288],"genre_scores_gemma":[0.9927078,0.001495712,0.0003824842,0.001973671,0.0003274873,0.0003184766,0.00002969504,0.00002781641,0.002736877],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7056029,"threshold_uncertainty_score":0.9996302,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02702545990048791,"score_gpt":0.3752658411589677,"score_spread":0.3482403812584798,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}