{"id":"W4403605877","doi":"10.3390/biomedicines12102399","title":"The Generation of ROS by Exposure to Trihalomethanes Promotes the IκBα/NF-κB/p65 Complex Dissociation in Human Lung Fibroblast","year":2024,"lang":"en","type":"article","venue":"Biomedicines","topic":"Sulfur Compounds in Biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Instituto Politécnico Nacional","keywords":"Fibroblast; Dissociation (chemistry); NF-κB; Cell biology; Human lung; Chemistry; Lung; Cancer research; Biology; Medicine; Biochemistry; Internal medicine; Signal transduction; In vitro","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004528868,0.0001296665,0.0001416695,0.00007085768,0.0001242837,0.00003333666,0.0002374037,0.000118243,0.00001008574],"category_scores_gemma":[0.0001894767,0.00007340369,0.00005131754,0.0002934499,0.0001857319,0.000003729137,0.00007946782,0.00006783768,0.000002039948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002474137,"about_ca_system_score_gemma":0.0000316737,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005624515,"about_ca_topic_score_gemma":0.0001804508,"domain_scores_codex":[0.9989666,0.0001421583,0.0003039502,0.0002612905,0.0001400868,0.000185909],"domain_scores_gemma":[0.9994605,0.0001076682,0.0000700613,0.0002612699,0.00006998615,0.00003054626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001954996,0.00002198753,0.001580525,0.00002817146,0.00004058889,7.634433e-7,0.0002791078,0.000005474359,0.969497,0.0001022725,0.02609599,0.002328597],"study_design_scores_gemma":[0.0006799907,0.001219415,0.01177027,0.000136271,0.00003914644,0.00001691968,0.0005795776,0.0008152833,0.8821409,0.0002426681,0.1020919,0.0002676935],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.989814,0.004836055,0.0003317188,0.004081192,0.0003797747,0.0003976494,0.00004440127,0.00001695622,0.00009824209],"genre_scores_gemma":[0.997976,0.0001112106,0.00007870703,0.0001456906,0.0007091635,0.00007360354,0.0003904641,0.00001589676,0.0004992299],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08735609,"threshold_uncertainty_score":0.2993316,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02356126178980021,"score_gpt":0.3067025887368068,"score_spread":0.2831413269470066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}