{"id":"W4403609859","doi":"10.3390/brainsci14101039","title":"Heterogeneous Nuclear Ribonucleoprotein A1 Knockdown Alters Constituents of Nucleocytoplasmic Transport","year":2024,"lang":"en","type":"article","venue":"Brain Sciences","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Cameco (Canada)","funders":"","keywords":"Gene knockdown; Heterogeneous nuclear ribonucleoprotein; Nucleoporin; Lamin; Nuclear lamina; Nuclear pore; Biology; Cell biology; Heterogeneous ribonucleoprotein particle; Ribonucleoprotein; Cell nucleus; Nuclear protein; Nuclear transport; RNA-binding protein; Small nuclear ribonucleoprotein; Molecular biology; RNA; Cytoplasm; Cell culture; Genetics; Nucleus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001269342,0.0004161867,0.0002719227,0.0002687602,0.0002295881,0.0003779372,0.0002700138,0.0004074034,0.001645422],"category_scores_gemma":[0.0001386197,0.0001414529,0.000296092,0.0001494251,0.0003334351,0.0003003413,0.0001653041,0.000455087,0.0005005539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004373436,"about_ca_system_score_gemma":0.000230742,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001272626,"about_ca_topic_score_gemma":0.001590937,"domain_scores_codex":[0.9998848,0.00001118325,0.00001682872,0.00004044718,0.00002541686,0.00002136563],"domain_scores_gemma":[0.99985,0.00002658929,0.00005368844,0.00001730337,0.00002163106,0.00003089873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001049417,0.00002738729,0.000173686,0.00005508462,0.000008371193,0.00002998231,0.0000133405,0.0001235633,0.9985884,0.00007274937,0.00005262587,0.0007498978],"study_design_scores_gemma":[0.0000183052,0.0002585037,0.004921529,0.00001169075,0.00004017141,0.0001072112,0.00003874637,0.00252597,0.9901513,0.00005251121,0.001867471,0.000006737112],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9904327,0.001477889,0.004991358,0.0001291245,0.00004431744,0.00003824496,0.0008376403,0.0003506556,0.001698013],"genre_scores_gemma":[0.9939113,0.0008245032,0.002646752,0.00005729458,0.000006261925,0.00006609008,0.0007018396,0.00004839222,0.001737545],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001645422,"threshold_uncertainty_score":0.005504489,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009325913584865833,"score_gpt":0.2469753862166854,"score_spread":0.2376494726318195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}