{"id":"W4403609859","doi":"10.3390/brainsci14101039","title":"Heterogeneous Nuclear Ribonucleoprotein A1 Knockdown Alters Constituents of Nucleocytoplasmic Transport","year":2024,"lang":"en","type":"article","venue":"Brain Sciences","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Saskatchewan; Cameco (Canada)","funders":"","keywords":"Gene knockdown; Heterogeneous nuclear ribonucleoprotein; Nucleoporin; Lamin; Nuclear lamina; Nuclear pore; Biology; Cell biology; Heterogeneous ribonucleoprotein particle; Ribonucleoprotein; Cell nucleus; Nuclear protein; Nuclear transport; RNA-binding protein; Small nuclear ribonucleoprotein; Molecular biology; RNA; Cytoplasm; Cell culture; Genetics; Nucleus; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002023864,0.0001163203,0.0001124785,0.00007405125,0.000112858,0.00003815291,0.0002172925,0.00008825741,0.0001478925],"category_scores_gemma":[0.00002502937,0.00009808563,0.0001036563,0.0001908888,0.000486431,0.00001085062,0.00003699591,0.00006057651,0.00003487498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007336542,"about_ca_system_score_gemma":0.00007277638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003074394,"about_ca_topic_score_gemma":0.0000225192,"domain_scores_codex":[0.9990336,0.00002567046,0.0001769871,0.0003785472,0.0001908753,0.0001942631],"domain_scores_gemma":[0.9997008,0.00001128641,0.00003977535,0.0001681094,0.00002298556,0.00005697011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005943181,0.000024516,0.001034331,0.00006381196,0.00005440802,0.00002079951,0.0001843736,0.0002728066,0.9797043,0.002152552,0.004059084,0.0123696],"study_design_scores_gemma":[0.0007002164,0.001680178,0.003996593,0.0001856981,0.00006540543,0.0003936142,0.0003642638,0.001808864,0.3487921,0.001138657,0.6401624,0.000712005],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934471,0.0004826302,0.000191603,0.000370695,0.000512526,0.0001261069,0.00002415152,0.00003471834,0.004810435],"genre_scores_gemma":[0.9985189,0.00003981773,0.0006757839,0.0003786095,0.0001151829,0.000002383342,0.00001082263,0.00001465637,0.0002438608],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6361033,"threshold_uncertainty_score":0.3999816,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009325913584865833,"score_gpt":0.2469753862166854,"score_spread":0.2376494726318195,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}