{"id":"W4403615278","doi":"10.1002/alz.14276","title":"Association of CSF α‐synuclein seed amplification assay positivity with disease progression and cognitive decline: A longitudinal Alzheimer's Disease Neuroimaging Initiative study","year":2024,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institutes of Health; Genentech; IXICO; H. Lundbeck A/S; Servier; Eisai; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Bristol-Myers Squibb; Eli Lilly and Company; Biogen; BioClinica; Alzheimer's Disease Neuroimaging Initiative; Meso Scale Diagnostics; National Institute on Aging; Alzheimer's Association","keywords":"Cognitive decline; Neuroimaging; Alzheimer's Disease Neuroimaging Initiative; Cerebrospinal fluid; Disease; Internal medicine; Cognition; Medicine; Alzheimer's disease; Oncology; Pathology; Psychology; Dementia; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001779104,0.0005099083,0.0004711297,0.0007637027,0.0008756796,0.001065178,0.0005211344,0.0006724044,0.0008711693],"category_scores_gemma":[0.002473649,0.000418949,0.0006316433,0.0008147082,0.0002961468,0.0006828838,0.0007451007,0.0007687635,0.0003206582],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004292838,"about_ca_system_score_gemma":0.0005267373,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005243264,"about_ca_topic_score_gemma":0.007305966,"domain_scores_codex":[0.9995002,0.0001155848,0.00006994397,0.0001707216,0.00008246563,0.00006112712],"domain_scores_gemma":[0.998195,0.0001490165,0.0005858252,0.0001912698,0.0004600677,0.0004189332],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004976889,0.00009889746,0.9979899,0.00001175061,0.000136794,0.0000745357,0.0001393217,0.00001721147,0.0002998914,0.000008700334,0.00008803063,0.0006372495],"study_design_scores_gemma":[0.00002502139,0.0002965918,0.9989618,0.000006785874,0.00007820291,0.0002239368,0.0001212422,0.00008213191,0.0000757845,0.00001967425,0.0001042065,0.000004628442],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9990877,0.0001389675,0.00005993282,0.00001713897,0.000003539236,0.00002070326,0.0004387596,0.000003562782,0.0002297786],"genre_scores_gemma":[0.9985189,0.00007111416,0.0001524125,0.00002630226,0.000008793146,0.00003580499,0.001000638,0.000002512889,0.0001835281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005243264,"threshold_uncertainty_score":0.01042551,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03142318703444448,"score_gpt":0.3459128295305655,"score_spread":0.314489642496121,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}