{"id":"W4403616501","doi":"10.1007/s10549-024-07519-z","title":"CYP2D6 activity in patients with metastatic breast cancer treated with single agent tamoxifen: results from ECOG-ACRIN E3108","year":2024,"lang":"en","type":"article","venue":"Breast Cancer Research and Treatment","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":2,"is_retracted":false,"has_abstract":false,"ca_institutions":"BC Cancer Foundation; Spinal Cord Injury BC; BC Cancer Agency","funders":"Genomic Health; Foundation Medicine; Veracyte; Genentech; Max-Planck-Gesellschaft; Eisai; Puma Biotechnology; Natera; National Institutes of Health; ECOG-ACRIN Cancer Research Group; BeiGene; Susan G. Komen; Sanofi Genzyme; Pfizer; Incyte; American College of Radiology Imaging Network; National Cancer Institute; Gilead Sciences; Sanofi; Johns Hopkins University; Susan G. Komen for the Cure; Celgene; AstraZeneca; Eli Lilly and Company","keywords":"Tamoxifen; Medicine; Breast cancer; Oncology; Metastatic breast cancer; Cancer; Internal medicine; Mammary gland; Antiestrogen","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006718433,0.0006069202,0.001018549,0.000437384,0.0002024765,0.0005430233,0.0003217514,0.0006237431,0.0009276086],"category_scores_gemma":[0.001205843,0.0002278566,0.001069084,0.0008157219,0.0002267176,0.0003913835,0.0002801565,0.000696038,0.0002885424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004742407,"about_ca_system_score_gemma":0.0003056105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002578602,"about_ca_topic_score_gemma":0.003634325,"domain_scores_codex":[0.9995925,0.0001427296,0.00003069601,0.000093977,0.00008887192,0.00005123152],"domain_scores_gemma":[0.9993039,0.0001651528,0.0002428599,0.00006038778,0.00008564682,0.0001420191],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.05971272,0.001002136,0.895538,0.0001209732,0.002084149,0.0003763727,0.0001074867,0.0006797631,0.007622481,0.00004152835,0.00113977,0.03157471],"study_design_scores_gemma":[0.002924966,0.00657993,0.986016,0.00001182126,0.001180176,0.0005676031,0.00007279138,0.0005022428,0.0009496928,0.00004877828,0.00112789,0.00001816786],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964182,0.001374634,0.00009030468,0.0001187338,0.00001415085,0.00003452456,0.001266737,0.00001322935,0.0006694107],"genre_scores_gemma":[0.9958269,0.0006850538,0.0001465405,0.0001370224,0.00004541296,0.000025988,0.002578115,0.0000066068,0.0005482409],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002578602,"threshold_uncertainty_score":0.005127192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1497717271872898,"score_gpt":0.448820499447012,"score_spread":0.2990487722597222,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}