{"id":"W4403622129","doi":"10.58931/cht.2024.3255","title":"Treatment of Relapsed/Refractory Chronic Lymphocytic Leukemia After BTK Inhibitor and/or BCL-2 Inhibitor Failure","year":2024,"lang":"en","type":"article","venue":"Canadian Hematology Today","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen Elizabeth II Health Sciences Centre","funders":"","keywords":"Chronic lymphocytic leukemia; Refractory (planetary science); Bruton's tyrosine kinase; Ibrutinib; Medicine; Internal medicine; Cancer research; Leukemia; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003518441,0.0002527078,0.0005314848,0.000449114,0.0003470871,0.0004751029,0.0003091119,0.0004517544,0.002590686],"category_scores_gemma":[0.0005209655,0.00006538459,0.0004342615,0.0002578849,0.0002225054,0.0003297988,0.0003871912,0.0008344074,0.001088348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005929414,"about_ca_system_score_gemma":0.000374338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005393308,"about_ca_topic_score_gemma":0.002078965,"domain_scores_codex":[0.9998637,0.00003790229,0.00001234441,0.00001550658,0.00002485883,0.00004551481],"domain_scores_gemma":[0.9998589,0.00003320484,0.00002887215,0.000009094336,0.00001798688,0.00005198807],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.004994039,0.0007076818,0.01446193,0.001499658,0.0002853281,0.0140577,0.0004309014,0.001716522,0.0188875,0.003053273,0.05478193,0.8851236],"study_design_scores_gemma":[0.003971424,0.01513424,0.07312614,0.003837469,0.0005237897,0.08092078,0.0006320791,0.005564231,0.02334429,0.01331082,0.7794943,0.000140502],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.4967274,0.3805872,0.01456372,0.01404821,0.002629383,0.0007945894,0.001396294,0.001390074,0.08786308],"genre_scores_gemma":[0.9088261,0.06127083,0.004049057,0.007997942,0.001401881,0.0003104323,0.002015744,0.0001129811,0.014015],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.002590686,"threshold_uncertainty_score":0.008666694,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01358765583586513,"score_gpt":0.2729650758220165,"score_spread":0.2593774199861514,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}