{"id":"W4403623168","doi":"10.1097/hep.0000000000001132","title":"Fine-tuning of hepatitis C virus immune evasion through hypervariable region 1 insertions","year":2024,"lang":"en","type":"article","venue":"Hepatology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"National Cancer Institute; Centre National de la Recherche Scientifique; Agence Nationale de la Recherche; Natural Sciences and Engineering Research Council of Canada; European Commission; Styrelsen för Internationellt Utvecklingssamarbete; Université de Strasbourg; Institut National de la Santé et de la Recherche Médicale","keywords":"Hypervariable region; Evasion (ethics); Virology; Virus; Biology; Immune system; Hepatitis C virus; Immune escape; Antibody; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003438347,0.0002229189,0.0001538177,0.0001898714,0.0001432467,0.0004034658,0.000183514,0.0003136317,0.0007654428],"category_scores_gemma":[0.0005306595,0.0001399512,0.0002133677,0.0001013495,0.0002149978,0.0002485842,0.0002195159,0.0004229613,0.0002144702],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002145743,"about_ca_system_score_gemma":0.0001238047,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003453829,"about_ca_topic_score_gemma":0.0005961109,"domain_scores_codex":[0.9997949,0.00004519357,0.00001220151,0.00003825387,0.00004141132,0.0000681856],"domain_scores_gemma":[0.9997836,0.00008049851,0.0000623717,0.00001602321,0.0000219038,0.0000357073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001088142,0.0002266514,0.01407168,0.0002256324,0.0000673588,0.0003030208,0.0001185605,0.001004243,0.9542953,0.0005760561,0.0004207176,0.02760265],"study_design_scores_gemma":[0.00027744,0.005327834,0.1696801,0.000184053,0.0003095789,0.003688968,0.0005152579,0.0158451,0.784172,0.001225714,0.01867734,0.00009652242],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.995275,0.002487166,0.0008974776,0.00007209536,0.00003697089,0.00002310252,0.00009844829,0.00003976904,0.001069972],"genre_scores_gemma":[0.9982554,0.000587186,0.0005147016,0.0001326948,0.00001563687,0.00001111155,0.0001097861,0.00001195031,0.000361484],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007654428,"threshold_uncertainty_score":0.002560675,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06758468266677431,"score_gpt":0.3459088734229598,"score_spread":0.2783241907561855,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}