{"id":"W4403629137","doi":"10.1016/j.eururo.2024.10.014","title":"Sensitive Detection of Urothelial Cancer via High-volume Urine DNA Analysis","year":2024,"lang":"en","type":"letter","venue":"European Urology","topic":"Bladder and Urothelial Cancer Treatments","field":"Medicine","cited_by":13,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"Pirkanmaan Sairaanhoitopiiri; Orionin Tutkimussäätiö; Jane ja Aatos Erkon Säätiö; Tays; Suomen Lääketieteen Säätiö; Suomen Kulttuurirahasto; Academy of Finland","keywords":"Medicine; Urothelial cancer; Urine; Cancer; DNA; Volume (thermodynamics); Urology; Cancer detection; Bladder cancer; Oncology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001662935,0.0004640017,0.001052772,0.0007303686,0.00004921741,0.0000146704,0.000145628,0.0003888728,0.0008353798],"category_scores_gemma":[0.0000263899,0.000400361,0.00055623,0.0006285225,0.0001989138,0.00002886061,0.0001107857,0.001351352,0.0008730279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001481151,"about_ca_system_score_gemma":0.0001219006,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00113084,"about_ca_topic_score_gemma":0.0001209175,"domain_scores_codex":[0.9973739,0.0005038173,0.0005254442,0.0008147619,0.0003422769,0.0004397514],"domain_scores_gemma":[0.9988288,0.00006372242,0.0002468803,0.0005914193,0.0001772697,0.0000919485],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.002548927,0.000363529,0.002435699,0.001174892,0.0429886,0.03051738,0.001031839,0.0001689189,0.03357138,0.00001149334,0.853945,0.03124235],"study_design_scores_gemma":[0.001695284,0.001791706,0.0188394,0.00005416205,0.02513498,0.0003013284,0.000005471396,0.0002067821,0.006708717,0.00004499746,0.944768,0.000449165],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"empirical","genre_scores_codex":[0.07697307,0.005140388,0.007231749,0.8505371,0.00918059,0.002505535,0.003176542,0.0009256449,0.04432942],"genre_scores_gemma":[0.7074563,0.0001937394,0.00004879784,0.2659191,0.008027657,0.00003403419,0.0005323331,0.0002245707,0.01756344],"genre_candidate":"commentary","genre_consensus":null,"teacher_disagreement_score":0.6304832,"threshold_uncertainty_score":0.9999049,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01065306602502116,"score_gpt":0.2490575241801998,"score_spread":0.2384044581551787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}