{"id":"W4403630043","doi":"10.1182/blood.2024024769","title":"Ascorbate deficiency increases quiescence and self-renewal in hematopoietic stem cells and multipotent progenitors","year":2024,"lang":"en","type":"article","venue":"Blood","topic":"Vitamin C and Antioxidants Research","field":"Nursing","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University Health Network","funders":"Robert J. Kleberg, Jr. and Helen C. Kleberg Foundation; National Institutes of Health; University of Texas Southwestern Medical Center; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; Damon Runyon Cancer Research Foundation","keywords":"Haematopoiesis; Stem cell; Progenitor cell; Biology; Cell biology; Transplantation; Hematopoietic stem cell; Cancer research; Immunology; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009954484,0.0002056793,0.0001682429,0.0002489701,0.000108664,0.0002970831,0.0001469173,0.0002183076,0.001334282],"category_scores_gemma":[0.00009362905,0.0001014108,0.0001399923,0.0001412851,0.000154007,0.000176083,0.0002436565,0.0003420224,0.0002168697],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001612071,"about_ca_system_score_gemma":0.0001431409,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003242058,"about_ca_topic_score_gemma":0.0004210678,"domain_scores_codex":[0.9999161,0.00001598576,0.00001161458,0.0000164984,0.00002326148,0.00001667022],"domain_scores_gemma":[0.9998938,0.00001851668,0.0000244834,0.0000137021,0.00001148893,0.00003808496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001173789,0.00001416465,0.0003280442,0.00001764516,0.000003863296,0.0000243396,0.00001128067,0.00001414818,0.9986634,0.0000447839,0.00001372974,0.000747159],"study_design_scores_gemma":[0.00001512552,0.0002459946,0.006748875,0.000004817788,0.0000180755,0.0002215689,0.00002324618,0.0003418174,0.9905698,0.00004448755,0.001763948,0.000002274061],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973143,0.0009940272,0.001037377,0.00003222704,0.000006610248,0.000008994969,0.0001515046,0.00004723863,0.0004076983],"genre_scores_gemma":[0.9976072,0.000309511,0.0005580288,0.00001820123,0.000003477179,0.00001316077,0.0002614724,0.00001101574,0.001217888],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001334282,"threshold_uncertainty_score":0.004463613,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01156987136543873,"score_gpt":0.2543804890254547,"score_spread":0.242810617660016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}