{"id":"W4403654916","doi":"10.1038/s41467-024-53347-6","title":"Oral reovirus reshapes the gut microbiome and enhances antitumor immunity in colon cancer","year":2024,"lang":"en","type":"article","venue":"Nature Communications","topic":"Viral gastroenteritis research and epidemiology","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario; University of Ottawa","funders":"Ministry of Science and ICT, South Korea; National Research Foundation of Korea; Canadian Cancer Society Research Institute; National Research Foundation; Cancer Research Society","keywords":"Immunity; Microbiome; Gut microbiome; Cancer; Colorectal cancer; Immune system; Biology; Cancer research; Microbiology; Medicine; Virology; Immunology; Bioinformatics; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001688541,0.0003941108,0.0003108908,0.0001871807,0.000116536,0.0003178295,0.0001444863,0.0004038011,0.001191713],"category_scores_gemma":[0.00008654792,0.0001262838,0.0002787123,0.00009724273,0.000199519,0.0002343632,0.0001685807,0.0007787299,0.0003260109],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002859604,"about_ca_system_score_gemma":0.0002650864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004323524,"about_ca_topic_score_gemma":0.0009587712,"domain_scores_codex":[0.9998823,0.00001958797,0.000005580539,0.00001986959,0.00003802149,0.000034561],"domain_scores_gemma":[0.9999303,0.000009548075,0.00001870635,0.0000131011,0.000008095607,0.00002025241],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004813627,0.0001359433,0.0001648295,0.0001174345,0.000009722314,0.00006798811,0.0000167963,0.000144307,0.9890364,0.0001556682,0.0002695012,0.009400168],"study_design_scores_gemma":[0.0001069887,0.002890288,0.002243576,0.0000134996,0.00003673095,0.000315335,0.00002497634,0.0008253917,0.9859287,0.00007825756,0.007529381,0.000006784079],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9829888,0.007151544,0.004287166,0.0005870429,0.0002741146,0.0001093862,0.0002982133,0.0002915912,0.004012214],"genre_scores_gemma":[0.9881291,0.003782948,0.002459687,0.0001397598,0.00005612626,0.00005664523,0.0002076144,0.00003484945,0.005133295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001191713,"threshold_uncertainty_score":0.003986657,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04304621909172112,"score_gpt":0.4210741188620524,"score_spread":0.3780278997703313,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}