{"id":"W4403663151","doi":"10.1093/cercor/bhae423","title":"Longitudinal association of depressive symptoms with cognition and neuroimaging biomarkers in cognitively unimpaired older adults, mild cognitive impairment, and Alzheimer’s disease","year":2024,"lang":"en","type":"article","venue":"Cerebral Cortex","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"West China Hospital, Sichuan University; National Institutes of Health; H. Lundbeck A/S; Servier; Eisai; Genentech; IXICO; National Natural Science Foundation of China; Northern California Institute for Research and Education; Pfizer; Novartis Pharmaceuticals Corporation; University of Southern California; Sichuan University; Biogen; BioClinica; Eli Lilly and Company; Bristol-Myers Squibb; U.S. Department of Defense; Meso Scale Diagnostics; Alzheimer's Association; Canadian Institutes of Health Research; National Science Foundation","keywords":"Montreal Cognitive Assessment; Dementia; Cognition; Geriatric Depression Scale; Clinical Dementia Rating; Psychology; Neuroimaging; Depression (economics); Mini–Mental State Examination; Clinical psychology; Alzheimer's disease; Cognitive decline; Disease; Psychiatry; Medicine; Internal medicine; Cognitive impairment; Depressive symptoms","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00137493,0.0002945598,0.0004619069,0.0008820745,0.0003856582,0.0005503338,0.0003083387,0.0003962766,0.0003961271],"category_scores_gemma":[0.002777288,0.0002642306,0.0003968634,0.0008416233,0.0001955659,0.00038675,0.0004414243,0.0004401179,0.00008518372],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002914801,"about_ca_system_score_gemma":0.0003591451,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007755023,"about_ca_topic_score_gemma":0.01249586,"domain_scores_codex":[0.9996049,0.0001177863,0.00005904089,0.00008484717,0.00006322032,0.00007026755],"domain_scores_gemma":[0.9987747,0.0001833317,0.0005118717,0.0001016103,0.0002029522,0.0002255195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001116804,0.00003354675,0.9990724,0.000004522631,0.00004843621,0.00002784021,0.00003051133,0.00001676847,0.0001104828,0.000004673837,0.00001549563,0.0005235897],"study_design_scores_gemma":[0.000004396539,0.00007651609,0.9996777,0.000001465294,0.00002098756,0.00004920263,0.00003143933,0.0000765523,0.00002137478,0.000008860322,0.0000302708,0.000001356616],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9993518,0.0002913474,0.00005052475,0.00001588103,0.00000225465,0.000007042802,0.0001818103,0.000001344699,0.00009799447],"genre_scores_gemma":[0.9993373,0.00008697747,0.00009746302,0.00001877348,0.000006576687,0.00000979973,0.0003494893,5.128711e-7,0.00009318381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007755023,"threshold_uncertainty_score":0.01541972,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01426310737884704,"score_gpt":0.2864085398984209,"score_spread":0.2721454325195738,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}