{"id":"W4403665664","doi":"10.1093/bjd/ljae402","title":"Efficacy and safety of the ustekinumab biosimilar ABP 654 in patients with moderate-to-severe plaque psoriasis: a randomized double-blinded active-controlled comparative clinical study over 52 weeks","year":2024,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Biosimilars and Bioanalytical Methods","field":"Immunology and Microbiology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; University of Toronto","funders":"Amgen","keywords":"Ustekinumab; Medicine; Psoriasis Area and Severity Index; Randomized controlled trial; Clinical endpoint; Adverse effect; Internal medicine; Psoriasis; Randomization; Gastroenterology; Dermatology; Adalimumab; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003486456,0.001641594,0.003341974,0.0005470497,0.0006469465,0.001026468,0.001148853,0.0021637,0.006411639],"category_scores_gemma":[0.00265592,0.0009900522,0.001853473,0.0004957247,0.001275824,0.001383909,0.0004816444,0.002200543,0.001001188],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007410033,"about_ca_system_score_gemma":0.001357577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005160494,"about_ca_topic_score_gemma":0.00119166,"domain_scores_codex":[0.9985315,0.0007083406,0.0001436977,0.0002788176,0.0001812454,0.0001563974],"domain_scores_gemma":[0.9980896,0.0004283395,0.0005903688,0.0001680354,0.0002095079,0.000514132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9626287,0.02117992,0.0005371538,0.0004574317,0.0005137592,0.00002568759,0.00006000346,0.000163476,0.004625989,0.00004073138,0.0002517856,0.009515387],"study_design_scores_gemma":[0.7839866,0.2116227,0.002647374,0.00002401655,0.000384989,0.00002843264,0.00002064055,0.0002174217,0.0006305251,0.0000651606,0.0003567383,0.00001534117],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889889,0.002426752,0.0006319783,0.0002286417,0.0002089536,0.005696689,0.0005712725,0.00007666812,0.001170077],"genre_scores_gemma":[0.987783,0.001299007,0.001736659,0.000579907,0.0003518749,0.006019659,0.0005322815,0.00001841152,0.001679099],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006411639,"threshold_uncertainty_score":0.02144909,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02733701388696473,"score_gpt":0.3263798375749371,"score_spread":0.2990428236879724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}