{"id":"W4403667407","doi":"10.1093/bjd/ljae404","title":"Efficacy and safety of upadacitinib versus dupilumab in adults and adolescents with moderate-to-severe atopic dermatitis: week 16 results of an open-label randomized efficacy assessor-blinded head-to-head phase IIIb/IV study (Level Up)","year":2024,"lang":"en","type":"article","venue":"British Journal of Dermatology","topic":"Dermatology and Skin Diseases","field":"Medicine","cited_by":50,"is_retracted":false,"has_abstract":true,"ca_institutions":"Probity Medical Research; University of British Columbia","funders":"","keywords":"Eczema Area and Severity Index; Medicine; Atopic dermatitis; Clinical endpoint; Randomized controlled trial; Dupilumab; Adverse effect; Internal medicine; Dermatology; Clinical trial; Dermatology Life Quality Index; Severity of illness; Disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[{"model":"gemma","categories":[],"domain":null,"study_design":"randomized_trial","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"low","status":"direct model label, unvalidated"},{"model":"gpt","categories":[],"domain":null,"study_design":"randomized_trial","genre":"empirical","about_ca_system":false,"about_ca_topic":false,"confidence":"high","status":"direct model label, unvalidated"}],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006294827,0.0003494277,0.002447906,0.0005973127,0.0001125174,0.0001051743,0.000355456,0.000229054,0.00001528085],"category_scores_gemma":[0.001357461,0.0003266643,0.0000871746,0.0004792424,0.0003606347,0.0004762437,0.0001845028,0.0006051126,0.000002580138],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000541609,"about_ca_system_score_gemma":0.000480956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002117584,"about_ca_topic_score_gemma":0.0009335455,"domain_scores_codex":[0.9954237,0.0009850624,0.002153905,0.0005373238,0.0004552817,0.0004447447],"domain_scores_gemma":[0.9972997,0.0008397672,0.0005481756,0.0003127404,0.0004532534,0.0005464045],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9207219,0.01145233,0.009046418,0.001175691,0.0009687594,0.01715556,0.002753105,0.0000319706,0.00005272964,0.00003896057,0.001238508,0.03536403],"study_design_scores_gemma":[0.8113596,0.002829607,0.1360835,0.00994702,0.0006535305,0.03674666,0.000995404,0.0006270634,0.0003212346,0.00006045617,0.00006231459,0.000313599],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919589,0.003348368,0.0002985125,0.001265997,0.000301466,0.002498683,0.0001684879,0.0000256653,0.0001339111],"genre_scores_gemma":[0.9983728,0.0004176646,0.0007663638,0.0002731084,0.00003563313,0.00003422964,0.00003756822,0.00004389536,0.00001872411],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.127037,"threshold_uncertainty_score":0.9999185,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04700225101236575,"score_gpt":0.359323760572684,"score_spread":0.3123215095603182,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}