{"id":"W4403671648","doi":"10.1016/j.clcc.2024.10.002","title":"Neoadjuvant Treatment With Regorafenib and Capecitabine Combined With Radiotherapy in Locally Advanced Rectal Cancer: A Multicenter Phase Ib Trial (RECAP)–SAKK 41/16","year":2024,"lang":"en","type":"article","venue":"Clinical Colorectal Cancer","topic":"Colorectal Cancer Treatments and Studies","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Bayer Canada; Bayer Corporation","keywords":"Medicine; Capecitabine; Regorafenib; Colorectal cancer; Radiation therapy; Oncology; Internal medicine; Chemo-radiotherapy; Neoadjuvant therapy; Phases of clinical research; Chemotherapy; Cancer; Breast cancer","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002867887,0.0006919461,0.001662453,0.0001927476,0.0001388438,0.00008252198,0.0001122195,0.0002242824,0.0004239824],"category_scores_gemma":[0.00005714086,0.0004119423,0.0002619452,0.000626337,0.0005726198,0.00019156,0.00005186914,0.0005420853,0.000005830295],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001838409,"about_ca_system_score_gemma":0.001051592,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001373349,"about_ca_topic_score_gemma":0.01896155,"domain_scores_codex":[0.996448,0.0001593331,0.000927234,0.001279731,0.0004533588,0.0007323546],"domain_scores_gemma":[0.998325,0.0005644485,0.0001875482,0.0003096039,0.0001858075,0.0004276109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5933971,0.002646985,0.02237832,0.0001339726,0.001631897,0.0009780325,0.000792713,0.00002411238,0.0004275584,0.00001670817,0.0004904166,0.3770822],"study_design_scores_gemma":[0.6380817,0.2741354,0.02883283,0.003170752,0.001769428,0.0001415535,0.000662801,0.003973525,0.001834879,0.00002666238,0.0460878,0.001282684],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9555289,0.03453102,0.00003170979,0.00370585,0.001114504,0.004076535,0.0001555581,0.0001908705,0.0006650839],"genre_scores_gemma":[0.96921,0.02445904,0.0004650297,0.0004957237,0.0007649123,0.003192903,0.00004949373,0.0001161986,0.001246676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3757995,"threshold_uncertainty_score":0.9998332,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0323816881087118,"score_gpt":0.3890605521613176,"score_spread":0.3566788640526058,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}