{"id":"W4403690961","doi":"10.3390/cells13211748","title":"3D-Q-FISH/Telomere/TRF2 Nanotechnology Identifies a Progressively Disturbed Telomere/Shelterin/Lamin AC Complex as the Common Pathogenic, Molecular/Spatial Denominator of Classical Hodgkin Lymphoma","year":2024,"lang":"en","type":"review","venue":"Cells","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Ontario Genomics; McGill University; Jewish General Hospital","funders":"","keywords":"Telomere; Shelterin; Biology; Fish <Actinopterygii>; Genetics; Gene; Transcription factor; DNA-binding protein; Fishery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002330948,0.0007273568,0.001361058,0.0001688484,0.0001363048,0.0001166764,0.0009472433,0.001122895,0.00006724065],"category_scores_gemma":[0.00007353484,0.0005056828,0.0008022161,0.0003005797,0.0006295433,0.000005689068,0.0008439356,0.0004414233,0.0001509881],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007448583,"about_ca_system_score_gemma":0.0002749746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003122607,"about_ca_topic_score_gemma":0.00005191577,"domain_scores_codex":[0.9970264,0.0003826261,0.0008472601,0.0009565045,0.0002966363,0.0004905263],"domain_scores_gemma":[0.9980362,0.00005571106,0.000588462,0.001113084,0.0001032767,0.0001032844],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001072725,0.0001142233,0.000002547797,0.003630708,0.0007285653,0.0001305063,0.00004867496,4.058333e-7,0.1374055,0.0002909084,0.004816732,0.852724],"study_design_scores_gemma":[0.000319652,0.0004255961,0.00004121427,0.0008184806,0.001284854,0.0002620625,0.00003611136,0.000009237016,0.04659867,0.0001673901,0.9494677,0.0005690659],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.03634242,0.9588358,0.0001157358,0.0001669338,0.001697171,0.001581161,0.0004878569,0.00008243748,0.0006904975],"genre_scores_gemma":[0.09337261,0.9020134,0.0004111793,0.0002667509,0.000726875,0.0003335775,0.001246094,0.0003136018,0.001315933],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9446509,"threshold_uncertainty_score":0.9997395,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01417189204954795,"score_gpt":0.2845334449868445,"score_spread":0.2703615529372966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}