{"id":"W4403690961","doi":"10.3390/cells13211748","title":"3D-Q-FISH/Telomere/TRF2 Nanotechnology Identifies a Progressively Disturbed Telomere/Shelterin/Lamin AC Complex as the Common Pathogenic, Molecular/Spatial Denominator of Classical Hodgkin Lymphoma","year":2024,"lang":"en","type":"review","venue":"Cells","topic":"Nuclear Structure and Function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Manitoba; Ontario Genomics; McGill University; Jewish General Hospital","funders":"","keywords":"Telomere; Shelterin; Biology; Fish <Actinopterygii>; Genetics; Gene; Transcription factor; DNA-binding protein; Fishery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002819644,0.0002173815,0.000158188,0.0004722135,0.0001498153,0.0004258091,0.0001880684,0.0005697705,0.001220881],"category_scores_gemma":[0.0001729691,0.0001701173,0.0002286586,0.0002437627,0.000318505,0.0004167119,0.0002731744,0.0003397511,0.0003005654],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000311404,"about_ca_system_score_gemma":0.0001987921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007001361,"about_ca_topic_score_gemma":0.001096718,"domain_scores_codex":[0.9999003,0.00001190226,0.000008043389,0.0000247829,0.00003594899,0.00001894697],"domain_scores_gemma":[0.9999291,0.00001611738,0.00001461996,0.00001077247,0.00001907564,0.00001032772],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007330917,0.0000185757,0.00267924,0.0002517014,0.00002277256,0.0005908111,0.0001501671,0.0007548828,0.9800718,0.0007006417,0.0003601733,0.01432596],"study_design_scores_gemma":[0.00001854365,0.0002808141,0.02937914,0.00008599901,0.0001216904,0.005844202,0.0005355479,0.007665882,0.9232026,0.001317514,0.03150509,0.00004307989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"review","genre_scores_codex":[0.9360581,0.02377675,0.0313025,0.0006221238,0.00010473,0.00003742441,0.0003978214,0.0003374338,0.007363076],"genre_scores_gemma":[0.9691695,0.01088879,0.01514152,0.000236194,0.00003030523,0.00004037102,0.0003890406,0.00006009811,0.004044278],"genre_candidate":"review","genre_consensus":null,"teacher_disagreement_score":0.001220881,"threshold_uncertainty_score":0.004084229,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01417189204954795,"score_gpt":0.2845334449868445,"score_spread":0.2703615529372966,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}