{"id":"W4403691312","doi":"10.1186/s13195-024-01601-w","title":"Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites","year":2024,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Medical Research Council; Canadian Institutes of Health Research; Genentech; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; IXICO; Karl-Franzens-Universität Graz; National Institutes of Health; Österreichische Forschungsförderungsgesellschaft; Oesterreichische Nationalbank; Eisai; Austrian Science Fund; Medizinische Universität Graz; Texas Alzheimer's Research and Care Consortium; Vanderbilt University; EU Joint Programme – Neurodegenerative Disease Research; Biogen; University of Miami; BioClinica; Bristol-Myers Squibb; U.S. Department of Defense; Eli Lilly and Company; University of Pennsylvania; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; University of Southern California; University of Toronto; National Science Foundation; Case Western Reserve University; Brigham and Women's Hospital; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's Association; GHR Foundation; University of Washington","keywords":"Alzheimer's disease; Disease; Neurology; Geriatric psychiatry; Medicine; Mitochondrial DNA; Biomarker; Biology; Pathology; Psychiatry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0007456708,0.0005144179,0.0004467553,0.0002445886,0.0003998376,0.0002926964,0.0004074276,0.000481699,0.001726899],"category_scores_gemma":[0.0001335666,0.0004107538,0.0002414927,0.0008068911,0.0007959963,0.00003916181,0.0001875127,0.0005809749,0.0002251821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001018989,"about_ca_system_score_gemma":0.0004191287,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008341946,"about_ca_topic_score_gemma":0.00003322529,"domain_scores_codex":[0.9955156,0.000985606,0.0004534385,0.00132649,0.0007231874,0.0009956644],"domain_scores_gemma":[0.9979072,0.0002454869,0.00008956192,0.0007688223,0.0004323716,0.0005566188],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00345958,0.0004514233,0.005800838,0.00001311429,0.03343018,0.0003212051,0.0007156605,0.0000035131,0.8791713,0.0005607097,0.06150737,0.01456515],"study_design_scores_gemma":[0.00594761,0.001570775,0.004788792,0.0001161318,0.002834524,0.00018,0.0001774589,0.0001521892,0.6737289,0.0009051902,0.3083077,0.001290765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.780608,0.2095965,0.00008025439,0.002925453,0.001698806,0.002000436,0.0004261118,0.000222399,0.002442043],"genre_scores_gemma":[0.9866664,0.008316843,0.0005248224,0.0009840478,0.0008434224,0.0003188194,0.0007135471,0.000206208,0.001425846],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2468003,"threshold_uncertainty_score":0.9998344,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04746016374615052,"score_gpt":0.3331954777773031,"score_spread":0.2857353140311525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}