{"id":"W4403691312","doi":"10.1186/s13195-024-01601-w","title":"Blood-derived mitochondrial DNA copy number is associated with Alzheimer disease, Alzheimer-related biomarkers and serum metabolites","year":2024,"lang":"en","type":"article","venue":"Alzheimer s Research & Therapy","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; National Human Genome Research Institute; National Heart, Lung, and Blood Institute; National Institute on Aging; Medical Research Council; Canadian Institutes of Health Research; Genentech; U.S. National Library of Medicine; National Institute of Neurological Disorders and Stroke; IXICO; Karl-Franzens-Universität Graz; National Institutes of Health; Österreichische Forschungsförderungsgesellschaft; Oesterreichische Nationalbank; Eisai; Austrian Science Fund; Medizinische Universität Graz; Texas Alzheimer's Research and Care Consortium; Vanderbilt University; EU Joint Programme – Neurodegenerative Disease Research; Biogen; University of Miami; BioClinica; Bristol-Myers Squibb; U.S. Department of Defense; Eli Lilly and Company; University of Pennsylvania; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Wellcome Trust; University of Southern California; University of Toronto; National Science Foundation; Case Western Reserve University; Brigham and Women's Hospital; Alzheimer's Disease Neuroimaging Initiative; Alzheimer's Association; GHR Foundation; University of Washington","keywords":"Alzheimer's disease; Disease; Neurology; Geriatric psychiatry; Medicine; Mitochondrial DNA; Biomarker; Biology; Pathology; Psychiatry; Gene; Genetics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001772594,0.0004555403,0.0003802518,0.0008356419,0.0002611405,0.0005240081,0.000412648,0.0003866446,0.001678969],"category_scores_gemma":[0.007145874,0.0002151879,0.0005554212,0.000952753,0.0003003938,0.0003144907,0.0003358713,0.0004510167,0.0001790695],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002314661,"about_ca_system_score_gemma":0.0002350152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001205279,"about_ca_topic_score_gemma":0.001014637,"domain_scores_codex":[0.9992586,0.0002178042,0.0000860797,0.0002782842,0.0001087653,0.00005048738],"domain_scores_gemma":[0.99643,0.001275561,0.001447022,0.0004336631,0.0002225661,0.0001911762],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001346377,0.00006280056,0.9887174,0.0000590166,0.0005255829,0.0001118357,0.00005638196,0.0002383401,0.002999,0.0001251898,0.000153598,0.005604479],"study_design_scores_gemma":[0.00004028578,0.0002112987,0.995124,0.00001310425,0.0004409374,0.0004838177,0.00002470355,0.001348725,0.001291724,0.0006486866,0.0003639543,0.000008818356],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9945081,0.001476575,0.002374934,0.0001021763,0.00001845538,0.00002209296,0.00109674,0.00004248915,0.0003585403],"genre_scores_gemma":[0.9978353,0.0001481604,0.001254113,0.00002546012,0.00001476759,0.00001847567,0.0005212771,0.000007562064,0.0001749189],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001772594,"threshold_uncertainty_score":0.009374499,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04746016374615052,"score_gpt":0.3331954777773031,"score_spread":0.2857353140311525,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}