{"id":"W4403692681","doi":"10.1021/acsinfecdis.4c00359","title":"High-Throughput Discovery of Synthetic Siderophores for Trojan Horse Antibiotics","year":2024,"lang":"en","type":"article","venue":"ACS Infectious Diseases","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; University of Alberta","funders":"Canadian Institutes of Health Research; Michael G. DeGroote Institute for Infectious Disease Research, McMaster University; Norwegian Institute of Public Health; Canada Research Chairs; Directorate for Biological Sciences; Leibniz-Gemeinschaft; Ontario Research Foundation; University of Alberta; Natural Sciences and Engineering Research Council of Canada; McMaster University; Fonds der Chemischen Industrie; Deutsches Zentrum für Infektionsforschung","keywords":"Trojan horse; Antibiotics; Siderophore; Throughput; Biology; Microbiology; Virology; Computational biology; Computer science; Bacteria; Computer security; Genetics; Telecommunications","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002763249,0.0004857678,0.0005720279,0.0005727469,0.0001661457,0.0004338579,0.0002989162,0.0003734998,0.0009265892],"category_scores_gemma":[0.0002435071,0.0001936289,0.0003943226,0.0004511244,0.0001476318,0.000246096,0.0002839765,0.0004151379,0.000376265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000286643,"about_ca_system_score_gemma":0.0002586922,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000245693,"about_ca_topic_score_gemma":0.000927552,"domain_scores_codex":[0.999809,0.00004056606,0.00001218796,0.00003075277,0.00007874285,0.00002884856],"domain_scores_gemma":[0.9999007,0.00002323467,0.0000223042,0.000008455965,0.00002358232,0.00002172623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001361853,0.0001503059,0.000279241,0.0001837784,0.00002949711,0.0001459024,0.00002896109,0.001356625,0.9847097,0.0002726709,0.0002454784,0.01246164],"study_design_scores_gemma":[0.0001131279,0.002340731,0.001842001,0.00003048295,0.00006724749,0.0003310662,0.00003258557,0.003012141,0.981391,0.0001948625,0.01062484,0.00001995654],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9706694,0.007337009,0.01401578,0.0002868867,0.00005034037,0.0004280911,0.001641282,0.0003779714,0.005193138],"genre_scores_gemma":[0.9702012,0.006786469,0.01706848,0.0001657228,0.00002196303,0.0001887729,0.002027963,0.00006405803,0.003475404],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009265892,"threshold_uncertainty_score":0.00309974,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006444619662630028,"score_gpt":0.2543706287698006,"score_spread":0.2479260091071706,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}