{"id":"W4403701826","doi":"10.1101/2024.10.21.619493","title":"Spatial memory in Alzheimer’s disease 5XFAD mice is enhanced by XPO1 inhibitor KPT-330","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Government of New Brunswick; Université de Moncton","funders":"Canadian Institutes of Health Research; Northwestern University; National Institutes of Health; Brown University","keywords":"Disease; Internal medicine; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001937467,0.0006077717,0.0005091543,0.0006069726,0.0001803173,0.0003008116,0.0002722844,0.0005726298,0.002379045],"category_scores_gemma":[0.00009552306,0.0002041494,0.0003638357,0.0002377187,0.0003065966,0.0002765339,0.0001868449,0.001019003,0.0005734988],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002456804,"about_ca_system_score_gemma":0.0002266679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009200638,"about_ca_topic_score_gemma":0.001075976,"domain_scores_codex":[0.9998854,0.00001106638,0.00001394947,0.0000236972,0.00003050019,0.00003534954],"domain_scores_gemma":[0.999895,0.000009977262,0.00003713698,0.00001029087,0.00001038288,0.00003716132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009426515,0.0001776118,0.0002401108,0.00008157439,0.00001762043,0.000099034,0.00002090675,0.00008263221,0.995706,0.0001177521,0.0002479885,0.002266213],"study_design_scores_gemma":[0.0001246457,0.001428264,0.007971874,0.00002200382,0.00005017643,0.0003077956,0.00005327558,0.0009172049,0.9864289,0.0001486926,0.002534904,0.00001227995],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919659,0.001967524,0.001675533,0.0004323668,0.00007130403,0.00002710779,0.001691981,0.0003079537,0.00186033],"genre_scores_gemma":[0.9835604,0.001842925,0.003399372,0.0002318616,0.00003630936,0.0001009667,0.002491786,0.000111312,0.008224912],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002379045,"threshold_uncertainty_score":0.007958651,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01824829662788615,"score_gpt":0.2722950064696304,"score_spread":0.2540467098417443,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}