{"id":"W4403711303","doi":"10.1093/ibd/izae253","title":"Three-Year Efficacy and Safety of Mirikizumab Following 152 Weeks of Continuous Treatment for Ulcerative Colitis: Results From the LUCENT-3 Open-Label Extension Study","year":2024,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; McGill University Health Centre","funders":"Eli Lilly and Company","keywords":"Medicine; Ulcerative colitis; Internal medicine; Open label; Clinical trial; Gastroenterology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003217255,0.0007268626,0.001209754,0.000317464,0.0003461392,0.0007387171,0.0006502058,0.0009460241,0.001568192],"category_scores_gemma":[0.001591721,0.0002830064,0.001192036,0.0002856051,0.000569038,0.0006699376,0.0003558748,0.001501833,0.0006267334],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006288385,"about_ca_system_score_gemma":0.0005808383,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008974462,"about_ca_topic_score_gemma":0.001144448,"domain_scores_codex":[0.9990404,0.0004659224,0.00006135306,0.0001435189,0.0001358018,0.0001530388],"domain_scores_gemma":[0.9977991,0.0002901852,0.0007916243,0.0003168716,0.0001738361,0.0006283992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7537754,0.03876025,0.07362155,0.0004800537,0.001651993,0.0003173759,0.0005764983,0.001232662,0.02439946,0.00006644258,0.002606706,0.1025116],"study_design_scores_gemma":[0.124918,0.3932992,0.4733416,0.00006249317,0.001078157,0.0004028537,0.0001203716,0.001510694,0.003226436,0.00005921448,0.001909802,0.00007119744],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998401,0.0005141923,0.0001052026,0.00005138729,0.00000971673,0.0001608011,0.0003613129,0.00003194455,0.0003644252],"genre_scores_gemma":[0.9976141,0.0001735763,0.0002730777,0.0001445082,0.00003975939,0.0002026869,0.0009910737,0.00000776505,0.0005534881],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003217255,"threshold_uncertainty_score":0.01701462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01985164895909421,"score_gpt":0.2894762815572008,"score_spread":0.2696246325981066,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}