{"id":"W4403714557","doi":"10.1101/2024.10.21.619543","title":"WRAD core perturbation impairs DNA replication fidelity promoting immunoediting in pancreatic cancer","year":2024,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Child and Family Research Institute","funders":"","keywords":"Immunoediting; Pancreatic cancer; Biology; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009273674,0.0001942328,0.0002209271,0.000173948,0.00009577946,0.0002140195,0.0001242313,0.0002040175,0.001507408],"category_scores_gemma":[0.0000842787,0.0001216512,0.0001643825,0.0001231784,0.0001496982,0.0001457394,0.000203697,0.0004243455,0.0003588742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001681447,"about_ca_system_score_gemma":0.0001358374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003847822,"about_ca_topic_score_gemma":0.0003558577,"domain_scores_codex":[0.9999259,0.00001170045,0.000008989723,0.00001690406,0.00001700656,0.0000196061],"domain_scores_gemma":[0.999949,0.00000731213,0.0000124096,0.00001017757,0.000003338013,0.00001780456],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002211239,0.00003875266,0.0001635179,0.00002572047,0.000004597173,0.00003063717,0.000007120567,0.0000876639,0.9981732,0.00003534006,0.0000395559,0.001172804],"study_design_scores_gemma":[0.00001547388,0.0004226344,0.003255183,0.000002672667,0.00000748303,0.0001527443,0.00001794535,0.0006352907,0.9942232,0.00003473101,0.001230255,0.000002344375],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969284,0.0008841181,0.001030629,0.00005272424,0.00002182788,0.00001243747,0.0003183584,0.00008395978,0.0006675411],"genre_scores_gemma":[0.9960074,0.000473112,0.0008773092,0.00002615526,0.000003292849,0.00001815934,0.000519731,0.00001975189,0.002055206],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001507408,"threshold_uncertainty_score":0.005042732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01414009746812041,"score_gpt":0.2517293847577242,"score_spread":0.2375892872896037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}