{"id":"W4403716428","doi":"10.1111/ene.16255","title":"Plasma phosphorylated tau181 outperforms [18F] fluorodeoxyglucose positron emission tomography in the identification of early Alzheimer disease","year":2024,"lang":"en","type":"article","venue":"European Journal of Neurology","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Douglas Mental Health University Institute; Montreal Neurological Institute and Hospital","funders":"Fonds de Recherche du Québec - Santé; Canadian Institutes of Health Research; HORIZON EUROPE Framework Programme; University of California, San Diego; Genentech; National Institutes of Health; UK Dementia Research Institute; Vetenskapsrådet; Eisai; University of Southern California; University College London; EU Joint Programme – Neurodegenerative Disease Research; Weston Brain Institute; National Institute on Aging; National Institute for Health and Care Research; Northern California Institute for Research and Education; Hjärnfonden; European Commission; Familjen Erling-Perssons Stiftelse; Fondation Brain Canada; Biogen; BioClinica; Alzheimer's Association; Stiftelsen för Gamla Tjänarinnor; Eli Lilly and Company; U.S. Department of Defense; Alzheimer's Disease Neuroimaging Initiative; F. Hoffmann-La Roche; Bristol-Myers Squibb; Consortium canadien en neurodégénérescence associée au vieillissement; McGill University","keywords":"Positron emission tomography; Medicine; Cerebrospinal fluid; Fluorodeoxyglucose; Neuroimaging; Dementia; Nuclear medicine; Pathology; Internal medicine; Disease; Psychiatry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00167341,0.0005615443,0.0005020313,0.0004053581,0.000257703,0.0007993871,0.0002687536,0.0007359894,0.001028128],"category_scores_gemma":[0.004441332,0.0003334749,0.0003054983,0.0002533703,0.0002686283,0.0004525034,0.0002032329,0.0002909506,0.0004294417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002166167,"about_ca_system_score_gemma":0.0002054082,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001422641,"about_ca_topic_score_gemma":0.001408786,"domain_scores_codex":[0.9996289,0.0001427136,0.00002764203,0.0001118771,0.00005703039,0.00003173983],"domain_scores_gemma":[0.9981598,0.0008785066,0.000497897,0.0001235752,0.0002013033,0.0001388848],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02234306,0.0002977799,0.9052644,0.0001576311,0.0008361163,0.0005979812,0.0004701954,0.001068973,0.03169415,0.00009073265,0.0003634095,0.03681558],"study_design_scores_gemma":[0.0001215693,0.001830675,0.9871961,0.0000261642,0.0002885013,0.001124073,0.0001448179,0.003131167,0.005513879,0.0002533901,0.0003529184,0.00001667791],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998885,0.0006160052,0.0002113165,0.00002788917,0.000004713039,0.000004345048,0.00006394038,0.000009125519,0.0001775475],"genre_scores_gemma":[0.9995567,0.00006945775,0.0002157424,0.00001725027,0.00000735272,0.000002370131,0.00005204517,0.000002833469,0.00007623009],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00167341,"threshold_uncertainty_score":0.008849978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01912093714717985,"score_gpt":0.2798026829902585,"score_spread":0.2606817458430787,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}