{"id":"W4403716511","doi":"10.1021/jacs.4c09805","title":"Structural Plasticity as a Driver of the Maturation of Pro-Interleukin-18","year":2024,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"Erythrocyte Function and Pathophysiology","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Plasticity; Interleukin 1β; Interleukin; Cytokine; Internal medicine; Composite material","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007359836,0.0001007186,0.00008104404,0.00006320008,0.0001073872,0.0001980714,0.0001320407,0.0001847004,0.0005812307],"category_scores_gemma":[0.0001947032,0.0000976259,0.00006352171,0.00005523235,0.0001851472,0.0003278199,0.0001127888,0.0002477997,0.0000693676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001252484,"about_ca_system_score_gemma":0.0000903885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001950981,"about_ca_topic_score_gemma":0.0002501817,"domain_scores_codex":[0.9999611,0.000006413603,0.000001904048,0.000009602696,0.00001060337,0.00001038256],"domain_scores_gemma":[0.9999384,0.00001340179,0.00002623914,0.00000587999,0.000006239834,0.000009964174],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004778087,0.00001272393,0.001706891,0.0000143962,0.000003703686,0.0000801501,0.00004965317,0.0006400745,0.9951195,0.0004177807,0.00002870709,0.001878711],"study_design_scores_gemma":[0.00002025885,0.0003961207,0.08094487,0.00001043616,0.00001856772,0.001107766,0.0002769023,0.02992675,0.8826561,0.001684627,0.002935431,0.00002226822],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967951,0.0002704267,0.002423759,0.00005034543,0.000003686125,0.000003651626,0.00002110025,0.00001872397,0.0004131545],"genre_scores_gemma":[0.9991828,0.000108033,0.0005525819,0.00001187584,0.000002068914,0.000002380256,0.00002154213,0.000002318773,0.0001164683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005812307,"threshold_uncertainty_score":0.001944423,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01486831967532021,"score_gpt":0.2816487390306124,"score_spread":0.2667804193552922,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}