{"id":"W4403722036","doi":"10.14309/01.ajg.0001034848.57615.ac","title":"S1370 Single Ascending Dose Results From a Phase 1 Clinical Trial of BT-600, a Combination Product of the NaviCap Targeted Oral Delivery Platform and Tofacitinib","year":2024,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celerion (Canada); Western University","funders":"","keywords":"Medicine; Tofacitinib; Clinical trial; Internal medicine; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002380633,0.001345668,0.002138253,0.0004044294,0.0003389491,0.000730527,0.0007096359,0.001428508,0.008096594],"category_scores_gemma":[0.001660034,0.0004570041,0.001498206,0.0003330247,0.0006001464,0.0008367965,0.0002827586,0.002527439,0.001356635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007875207,"about_ca_system_score_gemma":0.00159444,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007071897,"about_ca_topic_score_gemma":0.002050526,"domain_scores_codex":[0.9991117,0.0003834602,0.00007060399,0.0001509452,0.0001840694,0.0000992765],"domain_scores_gemma":[0.9988828,0.0002249283,0.0002975491,0.00008560754,0.0001448847,0.000364094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8085741,0.04057056,0.004562919,0.001339552,0.002444766,0.0002617952,0.0001567299,0.001478428,0.05702409,0.0002997218,0.0093885,0.07389888],"study_design_scores_gemma":[0.5079811,0.4662159,0.01237968,0.00006252529,0.001236412,0.0004523399,0.00003948456,0.0009203977,0.006349197,0.0002525451,0.004071607,0.00003888686],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9779763,0.003448757,0.00137194,0.0007281719,0.0002207536,0.00367817,0.007175085,0.0002255268,0.005175322],"genre_scores_gemma":[0.9739618,0.001757575,0.002764715,0.001533405,0.0002599657,0.002423765,0.0122652,0.00004974599,0.004983835],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008096594,"threshold_uncertainty_score":0.02708584,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1100061333905472,"score_gpt":0.4197077011805488,"score_spread":0.3097015677900016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}