{"id":"W4403722036","doi":"10.14309/01.ajg.0001034848.57615.ac","title":"S1370 Single Ascending Dose Results From a Phase 1 Clinical Trial of BT-600, a Combination Product of the NaviCap Targeted Oral Delivery Platform and Tofacitinib","year":2024,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Pharmaceutical studies and practices","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Celerion (Canada); Western University","funders":"","keywords":"Medicine; Tofacitinib; Clinical trial; Internal medicine; Rheumatoid arthritis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001625233,0.0001142979,0.0006871716,0.00006477434,0.0000552081,0.00001242481,0.0001689585,0.00002445206,0.00002091257],"category_scores_gemma":[0.0008978349,0.00005963174,0.0002111614,0.0001587166,0.0007458791,0.0001069625,0.0001052125,0.0005563583,6.277295e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002867676,"about_ca_system_score_gemma":0.0000575475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007351292,"about_ca_topic_score_gemma":0.000008684033,"domain_scores_codex":[0.9979354,0.0004935756,0.0009569997,0.0001577785,0.000261629,0.0001946552],"domain_scores_gemma":[0.997497,0.0009972361,0.001099052,0.0001720595,0.0001440505,0.00009066355],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8715353,0.002131781,0.01170012,0.00004665776,0.001732396,0.00007980217,0.001350294,0.000005610189,0.02202189,0.00003042299,0.0009523598,0.08841337],"study_design_scores_gemma":[0.4508329,0.3365015,0.1407901,0.001752651,0.007450841,0.002852916,0.006697571,0.003489372,0.01299307,0.001262833,0.03497884,0.0003974749],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.987647,0.0004854107,0.00005251608,0.01084341,0.0006013661,0.0002440054,0.00008505432,0.000005993686,0.00003523078],"genre_scores_gemma":[0.9982647,0.0005266755,0.0003221071,0.0005676498,0.0002945835,0.000001615065,0.000005628812,0.000009157826,0.000007936057],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4207024,"threshold_uncertainty_score":0.2748223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1100061333905472,"score_gpt":0.4197077011805488,"score_spread":0.3097015677900016,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}