{"id":"W4403722367","doi":"10.14309/01.ajg.0001035148.34102.cf","title":"S1445 Efficacy of Guselkumab vs Placebo in Crohn’s Disease Based on Prior Response/Exposure to Biologic Therapy: Results of the GALAXI 2 and 3 Phase 3 Studies","year":2024,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Crohn's disease; Placebo; Disease; Internal medicine; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00722236,0.001386397,0.004670595,0.0005796194,0.0002962273,0.001564897,0.0008071031,0.001953445,0.005348406],"category_scores_gemma":[0.006615806,0.0005483535,0.01032272,0.0008381911,0.0007988015,0.001169456,0.0006656779,0.002151236,0.0007375206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006575173,"about_ca_system_score_gemma":0.001027368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005944879,"about_ca_topic_score_gemma":0.001654404,"domain_scores_codex":[0.9957824,0.002784369,0.0004420769,0.0004777221,0.0003223757,0.0001910592],"domain_scores_gemma":[0.9955313,0.002029417,0.001525947,0.0003507879,0.0002660799,0.0002966002],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9090213,0.00106054,0.007234787,0.003651539,0.02382602,0.00005522732,0.00009385779,0.000816453,0.002957359,0.000167269,0.002522107,0.04859366],"study_design_scores_gemma":[0.76717,0.1009729,0.07407939,0.001058458,0.04289871,0.0002388161,0.0001416957,0.001958317,0.001787208,0.001368729,0.008173697,0.0001522185],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8994159,0.07928827,0.001933742,0.001796957,0.0008988429,0.002027652,0.009368034,0.0002569582,0.005013681],"genre_scores_gemma":[0.9788856,0.008483285,0.001329764,0.001578981,0.0005456505,0.001475686,0.006285582,0.00005210435,0.00136333],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00722236,"threshold_uncertainty_score":0.03819591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01169720887993822,"score_gpt":0.2911323692492904,"score_spread":0.2794351603693521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}