{"id":"W4403723014","doi":"10.14309/01.ajg.0001035264.55313.d0","title":"S1474 Efficacy and Safety of Upadacitinib After 3 Years of Treatment in Patients With Moderately to Severely Active Ulcerative Colitis: Interim Long-Term Data From the Phase 3 Open-Label Extension Study (U-ACTIVATE)","year":2024,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Microscopic Colitis","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Medicine; Open label; Ulcerative colitis; Interim; Interim analysis; Internal medicine; Term (time); Gastroenterology; Clinical trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.002571904,0.0006287747,0.002030966,0.0003438591,0.0003569002,0.0010488,0.0005321212,0.001150113,0.002582346],"category_scores_gemma":[0.001276759,0.0003114034,0.001548964,0.0003870224,0.0004039064,0.0008476006,0.0003490838,0.001758631,0.0005230588],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004970611,"about_ca_system_score_gemma":0.0007601746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005244276,"about_ca_topic_score_gemma":0.001578737,"domain_scores_codex":[0.9993586,0.0002840358,0.00006162073,0.00006878958,0.00008744118,0.0001395317],"domain_scores_gemma":[0.999132,0.0001927082,0.0003038806,0.00006590029,0.00007993549,0.0002256624],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7930483,0.01251003,0.03157889,0.001477475,0.002808399,0.0003223312,0.0002597829,0.001644349,0.014168,0.0001910675,0.007308634,0.1346828],"study_design_scores_gemma":[0.2823745,0.5082434,0.1883513,0.0002148314,0.003349854,0.0007960588,0.0001684785,0.002698189,0.006888369,0.0002712021,0.006519615,0.0001242043],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894696,0.004496519,0.0003280952,0.00027003,0.00007014315,0.000929396,0.002129546,0.00007800238,0.002228449],"genre_scores_gemma":[0.9927678,0.00094161,0.0004857149,0.0004161523,0.0001149671,0.0006944336,0.003240398,0.00001082332,0.001328044],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002582346,"threshold_uncertainty_score":0.01360172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04388964292789695,"score_gpt":0.3615386045758706,"score_spread":0.3176489616479737,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}