{"id":"W4403725071","doi":"10.14309/01.ajg.0001033584.02704.16","title":"S1054 TUSCANY-2: A Dose-Ranging Phase IIb Study Evaluating Efficacy and Safety of RO7790121, an Antibody Against Tumor Necrosis Factor-Like Ligand 1A (Anti-TL1A) in Adults With Moderately to Severely Active Ulcerative Colitis","year":2024,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McGill University Health Centre","funders":"","keywords":"Medicine; Dose-ranging study; Tumor necrosis factor alpha; Antibody; Internal medicine; Pharmacology; Immunology; Oncology; Pathology; Alternative medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001556337,0.001536255,0.001603071,0.0005549177,0.0004685484,0.0008313242,0.0007586592,0.001452215,0.00555836],"category_scores_gemma":[0.0006349515,0.0005804924,0.001275233,0.0004896781,0.001154186,0.0004987184,0.0004047486,0.002683981,0.001053749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008846414,"about_ca_system_score_gemma":0.001375791,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002065119,"about_ca_topic_score_gemma":0.004369678,"domain_scores_codex":[0.9995702,0.000224351,0.00001862059,0.00005138049,0.00003750161,0.00009799562],"domain_scores_gemma":[0.9994549,0.00008597903,0.0001205154,0.00003592451,0.00003332512,0.0002692795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8422239,0.0364565,0.006010174,0.0008531156,0.001216806,0.0004063086,0.0002402931,0.001132764,0.06059598,0.000217349,0.003541246,0.04710558],"study_design_scores_gemma":[0.6694729,0.3115637,0.01249135,0.00003270575,0.0004442278,0.0002088796,0.00003543553,0.0003774368,0.003302837,0.00005177292,0.00199861,0.00002020412],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9903336,0.002737643,0.000339603,0.0005211799,0.00009958435,0.002303021,0.001123275,0.000117902,0.002424173],"genre_scores_gemma":[0.9875595,0.001895094,0.0007220234,0.0008015034,0.0002748704,0.001915432,0.003283482,0.00002982707,0.003518302],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00555836,"threshold_uncertainty_score":0.01859462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01039172776163247,"score_gpt":0.3082713727594963,"score_spread":0.2978796449978638,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}