{"id":"W4403725241","doi":"10.14309/01.ajg.0001033580.05809.96","title":"S1053 Week 48 Efficacy Of Guselkumab And Ustekinumab In Crohn’s Disease Based On Prior Response/Exposure To Biologic Therapy: Results From The GALAXI 2 and 3 Phase 3 Studies","year":2024,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Inflammatory Bowel Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Calgary","funders":"","keywords":"Medicine; Ustekinumab; Crohn's disease; Dermatology; Internal medicine; Gastroenterology; Disease; Adalimumab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.004534747,0.0009744267,0.002519793,0.0003851576,0.0003423899,0.001203536,0.0006204179,0.001359208,0.008104318],"category_scores_gemma":[0.003558882,0.0005231503,0.005569069,0.0005845811,0.0006229898,0.0008790977,0.0006548942,0.001945867,0.001196694],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005882641,"about_ca_system_score_gemma":0.001105201,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007313291,"about_ca_topic_score_gemma":0.002233488,"domain_scores_codex":[0.9980755,0.001057478,0.0002282496,0.0002581794,0.0002227707,0.0001578494],"domain_scores_gemma":[0.9977557,0.0007323988,0.0008892669,0.0002455175,0.0001551612,0.0002219905],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8957777,0.002664347,0.01731266,0.00325535,0.01305586,0.00008865479,0.0001326887,0.0008829784,0.006270068,0.0001670514,0.004817281,0.05557527],"study_design_scores_gemma":[0.6330606,0.1327348,0.1899184,0.0008956364,0.02538784,0.0003394455,0.0001633344,0.001440898,0.003484417,0.0008601603,0.01156725,0.0001472749],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9581665,0.01931768,0.001346485,0.0008847104,0.0002836788,0.002731524,0.01226955,0.0001859166,0.004813862],"genre_scores_gemma":[0.9796962,0.003510562,0.001423541,0.001156893,0.0002473373,0.003069012,0.008682138,0.00005427594,0.002160128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008104318,"threshold_uncertainty_score":0.02711165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01551866583364382,"score_gpt":0.2894872777358482,"score_spread":0.2739686119022044,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}