{"id":"W4403725781","doi":"10.14309/01.ajg.0001031668.90104.a9","title":"S575 Dupilumab Efficacy in Children With Eosinophilic Esophagitis and Prior Use of or Prior Inadequate Response, Intolerance, or Contraindication to Swallowed Topical Corticosteroids: Results From the Phase 3 EoE KIDS Study","year":2024,"lang":"en","type":"article","venue":"The American Journal of Gastroenterology","topic":"Eosinophilic Esophagitis","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Medicine; Eosinophilic esophagitis; Contraindication; Dupilumab; Dermatology; Internal medicine; Gastroenterology; Atopic dermatitis; Disease; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001635267,0.0004314914,0.00132418,0.0001817446,0.0001927822,0.0006655599,0.0003919181,0.0006747054,0.002859048],"category_scores_gemma":[0.001536158,0.000241311,0.002158995,0.0002946575,0.0003022982,0.0004413751,0.0002791468,0.001215247,0.000405135],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006803997,"about_ca_system_score_gemma":0.0007974469,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00117827,"about_ca_topic_score_gemma":0.003918033,"domain_scores_codex":[0.9993829,0.0002890362,0.0000644451,0.00009280282,0.00008880796,0.0000821189],"domain_scores_gemma":[0.9986842,0.0003896561,0.000469751,0.00007459125,0.0001092544,0.0002724423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5995049,0.006805463,0.1314875,0.004925587,0.01236459,0.0006898636,0.0003932691,0.00191794,0.01896123,0.0004047304,0.01104668,0.2114982],"study_design_scores_gemma":[0.3089793,0.2705399,0.381915,0.0009840966,0.01249656,0.002261631,0.0002809828,0.002301814,0.006142488,0.0002703854,0.01372633,0.0001014259],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9807656,0.01329853,0.0001810992,0.0003339792,0.00008816234,0.0002986139,0.003184922,0.00003214461,0.001817015],"genre_scores_gemma":[0.9910985,0.003303294,0.0006194542,0.0006323608,0.00009835693,0.0002757605,0.003308753,0.00001138636,0.0006522119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002859048,"threshold_uncertainty_score":0.009564519,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02231173749289026,"score_gpt":0.3091066426584124,"score_spread":0.2867949051655221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}